Izloženost živi i funkcija štitaste žlezde: postoji li veza?

  • Djurdjica Marić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Vera Bonderović Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Dragana Javorac Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Katarina Baralić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Zorica Bulat Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Danijela Djukić-Ćosić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Stefan Mandić-Rajčević Univerzitet u Beogradu – Medicinski fakultet, Institut za socijalnu medicinu
  • Miloš Žarković Odeljenje za endokrinologiju, dijabetes i bolesti metabolizma
  • Aleksandra Buha Djordjević Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
DOI: https://doi.org/10.5937/arhfarm72-40122
Ključne reči: endokrini ometači, živa, funkcija štitaste žlezde, BMD koncept, nearest neighbor matching

Sažetak


Živa (Hg) je jedan od najznačajnijih zagađivača životne sredine sa osobinama endokrinog ometača. Malo je podataka iz epidemioloških studija koji opisuju odnos doza-odgovor između nivoa toksičnih metala i nivoa hormona. Cilj ovog rada bio je da primenom nearest neighbor matching analize utvrdi razlika u koncentraciji Hg kod zdravih/obolelih ispitanika od bolesti štitaste žlezde i da primenom Benchmark modelovanja utvrdi odnos doza-odgovor između nivoa Hg u krvi i tireostimulišućeg hormona (TSH) i tiroidnih hormona u serumu. Uzorci krvi su sakupljeni i korišćeni za merenje Hg uz pomoć ICP-MS metode, a izdvojeni serum korišćen je za analizu hormona. Studija je pokazala postojanje statistički značajne razlike u nivoima Hg koji su izmereni kod zdravih i bolesnih ispitanika i postojanje odnosa doza-odgovor između Hg i svih merenih hormona, pri čemu je uzak interval dobijen za Hg-TSH par. Rezultati ovog istraživanja podržavaju upotrebu Benchmark dose pristupa u svrhu analize podataka iz humanih studija, a naša dalja istraživanja će biti usmerena na ispitivanje uticaja niskih doza na životinjskim modelima, u cilju utvrđivanja preciznijih efekata niskih doza na organizam. 

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Objavljeno
2022/10/31
Broj časopisa
Vol. 72 Br. Notebook 5 (2022): Arhiv za farmaciju
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Originalni naučni rad
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