Mikrobiološki kvalitet probiotičkih proizvoda

  • Gordana Zavišić Univerzitet Privredna akademija u Novom Sadu, Farmaceutski fakultet
  • Slavica Ristić Univerzitet u Beogradu – Medicinski fakultet, Institut za medicinsku i kliničku biohemiju http://orcid.org/0000-0002-6983-4412
  • Branka Petković Univerzitet u Beogradu – Institut za biološka istraživanja “Siniša Stanković” – Institut od nacionalnog značaja za Republiku Srbiju, Odeljenje za neurofiziologiju http://orcid.org/0000-0001-7817-4092
  • Dragoslava Živkov Šaponja Univerzitet Privredna akademija u Novom Sadu, Farmaceutski fakultet
  • Nikola Jojić Univerzitet Privredna akademija u Novom Sadu, Farmaceutski fakultet https://orcid.org/0000-0002-9926-7658
  • Drina Janković Univerzitet u Beogradu, Institut za nuklearne nauke “Vinča” – Institut od nacionalnog značaja za Republiku Srbiju
DOI: https://doi.org/10.5937/arhfarm73-42160
Ključne reči: probiotik, mikrobiološki kvalitet, bezbednost, stabilnost

Sažetak


Mikroorganizmi koji se koriste kao probiotici treba da zadovolje elementarne aspekte bezbednosti (netoksičnost, odsustvo gena rezistencije na antibiotike i translokacije) i funkcionalne/tehnološke aspekte (otpornost i preživljavanje u kiselom gastričnom okruženju, adhezivnost, stabilnost i vijabilnost ćelija). Probiotici sa zdravstvenom tvrdnjom, bilo da su dijetetski proizvod ili farmabiotik (kategorija lekova), treba da budu klinički testirani, validirani, dokumentovani i stalno kontrolisani u pogledu kvaliteta. Važni parametri kvaliteta su identifikacija deklarisanih probiotičkih sojeva, broj živih mikroorganizama (probiotičke bakterije i/ili gljivice) i mikrobiološka čistoća (odsustvo specifičnih patogenih/uslovno patogenih bakterija i gljivica, kao i ograničavanje ukupnog broja kontaminanata kao što su aerobne bakterije, kvasci i plesni). Zbog brojnih izveštaja o komercijalnim probioticima niskog kvaliteta koji se prodaju za ljudsku upotrebu, ovaj pregled razmatra metode koje se koriste za testiranje sadržaja probiotičkih mikroorganizama, bezbednost za nameravanu upotrebu i dokazane zdravstvene koristi onih probiotika čiji mikrobiološki kvalitet odstupa od sadržaja koji tvrde proizvođači i održavanja vitalnosti ćelija, tj. stabilnosti probiotika tokom roka trajanja. Pored toga, razmatraju se i neželjeni efekti probiotika i potencijalne opasnosti po zdravlje korisnika.

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Objavljeno
2023/02/27
Broj časopisa
Vol. 73 Br. Notebook 1 (2023): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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