Upravljanje resursima u HPLC: Otkrivanje zelenog lica farmaceutske analize

  • Jevrem Stojanović Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za analitiku lekova
  • Jovana Krmar Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za analitiku lekova
  • Biljana Otašević Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za analitiku lekova
  • Ana Protić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za analitiku lekova
DOI: https://doi.org/10.5937/arhfarm73-43479
Ključne reči: Tečna hromatografija visokih performansi, procena ekološke prihvatljivosti metode, održivost

Sažetak


Tečna hromatografija pod visokim pritiskom (HPLC) je tehnika od ogromne važnosti u analitici lekova zbog svoje mogućnosti da razdvoji umereno do manje polarna jedinjenja, kao što su aktivne farmaceutske i srodne supstance. Koncept zelene analitičke hemije (GAC) ima za cilj da obezbedi ekološki prihvatljivije i bezbednije metode u pogledu reagenasa, energije i otpada. Jedan od glavnih izazova GAC je da pronađe odgovarajući pristup za procenu „zelenosti“ analitičkih metoda. Proširenje GAC, nazvano bela analitička hemija (WAC), uvedeno je kako bi se uzela u obzir ne samo ekološka prihvatljivost, već i drugi aspekti koji doprinose održivosti metoda, kao što su analitička i ekonomska ili praktična efikasnost. HPLC metode suštinski nisu „zelene“ zbog obimne potrošnje toksičnih organskih rastvarača i posledičnog stvaranja velikih količina toksičnog otpada. Srećom, postoji mnogo pristupa za prevazilaženje ne-zelene prirode HPLC metoda. U ovom radu su predstavljene različite modifikacije HPLC metode koje povećavaju ekološku prihvatljivost, kao i različiti alati koji se koriste za procenu ekološke prihvatljivosti. Pored toga, predstavljen je novi koncept bele analitičke hemije.

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Objavljeno
2023/04/26
Broj časopisa
Vol. 73 Br. Notebook 2 (2023): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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