Kvantitativna evaluacija profila rastvaranja - od jednostavnih do naprednih hemometrijskih pristupa

  • Łukasz Komsta Medical University of Lublin, Faculty of Pharmacy, Department of Medicinal Chemistry
  • Katarzyna Wicha-Komsta Medical University of Lublin, Faculty of Medicine, Department of Experimental and Clinical Pharmacology
DOI: https://doi.org/10.5937/arhfarm74-49757
Ključne reči: profili rastvaranja, metode zavisne od modela, metode nezavisne od modela, hemometrija

Sažetak


Različiti oblici lekova dizajnirani su da se rastvore nakon oralne primene. Kinetika i efikasnost ovog procesa su ključni parametri koje treba kontrolisati. Metode za njihovu evaluaciju su opisane u zvaničnim smernicama koje su izdale Agencija za hranu i lekove (eng. Food and Drug Administration, FDA), Evropska agencija za lekove (eng. European Medicines Agency, EMA) i Svetska zdravstvena organizacija (eng. World Health Organization, SZO). Predloženo je mnogo pristupa za upoređivanje, jer ove smernice nisu ograničene na određenu matematičku metodu. Ovaj rezime predstavlja trenutno stanje u pogledu ove teme, obuhvatajući kako metode zavisne od modela, tako i metode nezavisne od modela, kao i multivarijantne ideje. Reference su odabrane kao najvažniji radovi u oblasti, tako da ih čitaoci mogu smatrati najboljim preporukama za dalje čitanje.

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Objavljeno
2024/04/28
Broj časopisa
Vol. 74 Br. Notebook 2 (2024): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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