Biohemija i laboratorijska dijagnostika gojaznosti
Laboratorijska dijagnostika gojaznosti
Sažetak
Do sada je sprovedeno dosta istraživanja koja su značajno pomogla u sagledavanju i rešavanju problema gojaznosti. I pored toga, gojaznost ima trend porasta na globalnom nivou. Uloga laboratorijske dijagnostike u oblasti gojaznosti je od velikog značaja lekarima za postavljanje dijagnoze i praćenje efekata terapije. Određivanje biohemijskih parametara takođe doprinosi praktičnoj korisnosti u prevenciji ovog oboljenja, kao i predupređenju posledičnih komplikacija. Obično se za postavljanje dijagnoze i praćenje efekata terapije gojaznosti određuju rutinski dostupne biohemijske analize. Prvobitna asocijacija vezana za laboratorijske analize odnosi se na parametre lipidnog statusa, ali jako je veliki broj rutinskih analiza koje mogu pomoći u sagledavanju i praćenju gojaznosti iz različitih uglova. Dodatno, pravovremeno i adekvatno upravljanje gojaznošću je od interesa i sa ekonomskog aspekta. Iz tog razloga, tema ovog istraživanja je sumiranje najnovijih aspekata koncepta gojaznosti, posebno sa stanovišta biohemije i laboratorijske dijagnostike. Uzimajući u obzir složenost ove bolesti, važno je ukazati na buduće perspektive i izazove koji se neizbežno javljaju kako pred laboratorijskim stručnjacima, tako i pred zdravstvenim radnicima uopšte.
Reference
World Health Organization [Internet]. Obesity and overweight [cited 2024 Mar 29]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
World Obesity Day: ‘Missing the targets report’ [Internet]. [cited 2024 Mar 29]. Available from: https://www.worldobesity.org/resources/resource-library/world-obesity-day-missing-the-targets-report.
Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33(7):673-89.
OECD. The heavy burden of obesity: The economics of prevention, OECD Health Policy Studies. Paris: OECD Publishing; 2019.
Wells JC, Marphatia AA, Cole TJ, McCoy D. Associations of economic and gender inequality with global obesity prevalence: understanding the female excess. Soc Sci Med. 2012;75(3):482-90.
Spyrou N, Avgerinos KI, Mantzoros CS, Dalamaga M. Classic and novel adipocytokines at the intersection of obesity and cancer: Diagnostic and therapeutic strategies. Curr Obes Rep. 2018;7:260-75.
Kalra S, Kapoor N, Bhattacharya S, Aydin H, Coetzee A. Barocrinology: The endocrinology of obesity from bench to bedside. Med Sci (Basel). 2020;8:51.
Atri A, Jiwanmall SA, Nandyal MB, Kattula D, Paravathareddy S, Paul TV, et al. The prevalence and predictors of non-alcoholic fatty liver disease in morbidly obese women – A cross-sectional study from Southern India. Eur Endocrinol. 2020;16:152-5.
Kapoor N, Arora S, Kalra S. Gender disparities in people living with obesity - an unchartered territory. J Midlife Health. 2021;12(2):103-7.
Blüher S, Schwarz P. Metabolically healthy obesity from childhood to adulthood—does weight status alone matter? Metabolism. 2014;63(9):1084-92.
Longo M, Zatterale F, Naderi J, Parrillo L, Formisano P, Raciti GA, et al. Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. Int J Mol Sci. 2019;20(9):2358.
Patel P, Abate N. Body fat distribution and insulin resistance. Nutrients. 2013;5(6):2019-27.
Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376(3):254-66.
Vekic J, Zeljkovic A, Al Rasadi K, Cesur M, Silva-Nunes J, Stoian AP, Rizzo M. A New look at novel cardiovascular risk biomarkers: the role of atherogenic lipoproteins and innovative antidiabetic therapies. Metabolites. 2022;12(2):108.
Dubinina IA, Chistiakov DA, Eremina IA, Brovkin AN, Zilberman LI, Nikitin AG, et al. Studying progression from glucose intolerance to type 2 diabetes in obese children. Diabetes Metab Syndr. 2014;8(3):133-7.
Vekic J, Stefanovic A, Zeljkovic A. Obesity and dyslipidemia: A review of current evidence. Curr Obes Rep. 2023;12:207-22.
Stefanović A, Kotur-Stevuljević J, Spasić S, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Jelić-Ivanović Z. HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. Clin Biochem. 2010;43(15):1230-5.
Janac JM, Zeljkovic A, Jelic-Ivanovic ZD, Dimitrijevic-Sreckovic VS, Vekic J, Miljkovic MM, et al. Increased oxidized high-density lipoprotein/high-density lipoprotein–cholesterol ratio as a potential indicator of disturbed metabolic health in overweight and obese individuals. Lab Med. 2020;51(1):24–33.
Perovic Blagojevic IM, Vekic JZ, Macut DP, Ignjatovic SD, Miljkovic-Trailovic MM, Zeljkovic AR, et al. Overweight and obesity in polycystic ovary syndrome: association with inflammation, oxidative stress and dyslipidaemia. Br J Nutr. 2022;128(4):604-12.
Vekic J, Zeljkovic A, Cicero AFG, Janez A, Stoian AP, Sonmez A, Rizzo M. Atherosclerosis development and progression: the role of atherogenic small, dense LDL. Medicina. 2022;58(2):299.
Vekic J, Stromsnes K, Mazzalai S, Zeljkovic A, Rizzo M, Gambini J. Oxidative stress, atherogenic dyslipidemia, and cardiovascular risk. Biomedicines. 2023;11(11):2897.
Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V. Obesity and dyslipidemia. Metabolism. 2019;92:71-81.
Jovičić S, Ignjatović S, Dajak M, Majkić-Singh N. Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay. Clin Chem Lab Med. 2006;44(2):228-31.
Jovičić S, Ignjatović S, Dajak M, Kangrga R, Majkić-Singh N. Association of lipid and inflammatory markers with C-reactive protein in cardiovascular risk assessment for primary prevention. Clin Lab. 2009;55(11):411.
Koch VH. The effects of obesity on kidney function: a challenge for nephrologists. Braz J Nephrol. 2019;41(2):162-5.
Zhang T, Wang Q, Cui Xm, Zhang YY, Guo F, Wu Q, et al. Mediating effect of cumulative lipid profile burden on the effect of diet and obesity on hypertension incidence: a cohort study of people aged 35-65 in rural China. Eur J Clin Nutr. 2024;78:54-63.
Chang AR, Zafar W, Grams ME. Kidney function in obesity—challenges in indexing and estimation. Adv Chronic Kidney Dis. 2018;25(1):31-40.
Zeljković A, Mihajlović M, Vujčić S, Guzonjić A, Munjas J, Stefanović A, et al. The prospect of genomic, transcriptomic, epigenetic and metabolomic biomarkers for the personalized prevention of type 2 diabetes and cardiovascular diseases. Curr Vasc Pharmacol. 2023;21(3):185-96.
Vekic J, Zeljkovic A, Stefanovic A, Giglio RV, Ciaccio M, Rizzo M. Diabetes and Colorectal Cancer Risk: A new look at molecular mechanisms and potential role of Novel Antidiabetic Agents. Int J Mol Sci. 202;22(22):12409.
Chong B, Kong G, Shankar K, Chew HSJ, Lin C, Goh R, et al. The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000-2019. Metabolism. 2023;141:155402.
Belfiore F, Borzi V, Napoli E, Rabuazzo M. Enzymes related to lipogenesis in the adipose tissue of obese subjects. Metabolism. 1976;25(5):483–93.
Aarsland A, Chinkes D, Wolfe RR. Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. Am J Clin Nutr. 1997;65:1774–82.
Chascione C, Elwyn DH, Davila M, Gil KM, Askanazi J, Kinney JM. Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue. Am J Physiol. 1987;253:E664–9.
Mobbs CV, Makimura H. Block the FAS, lose the fat. Nat Med. 2002;8:335–6.
Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000;288:2379–81.
Kovacs P, Harper I, Hanson RL, Infante AM, Bogardus C, Tataranni PA, Baier LJ. A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Diabetes. 2004;53:1915–9.
Hillgartner FB, Salati LM, Goodridge AG. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol Rev. 1995;75:47–76.
Brownsey RW, Boone AN, Elliott JE, Kulpa JE, Lee WM. Regulation of acetyl-CoA carboxylase. Biochem Soc Trans. 2006;34:223–7.
Hudgins LC, Baday A, Hellerstein MK, Parker TS, Levine DM, Seidman CE, et al. The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects. J Nutr Biochem. 2008;19:237–45.
Ranganathan G, Unal R, Pokrovskaya I, Yao-Borengasser A, Phanavanh B, Lecka-Czernik B, et al. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res. 2006;47:2444–50.
Swierczynski J, Zabrocka L, Goyke E, Raczynska S, Adamonis W, Sledzinski Z. Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans. Mol Cell Biochem. 2003;254:55–9.
Ortega FJ, Mayas D, Moreno-Navarrete JM, Catalán V, Gómez-Ambrosi J, Esteve E, et al. The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. Obesity. 2009;18:13–20.
Berndt J, Kovacs P, Ruschke K, Klöting N, Fasshauer M, Schön MR, et al. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia. 2007;50:1472–80.
Poulain-Godefroy O, Lecoeur C, Pattou F, Frühbeck G, Froguel P. Inflammation is associated with a decrease of lipogenic factors in omental fat in women. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1–7.
Liu LH, Wang XK, Hu YD, Kang JL, Wang LL, Li S. Effects of a fatty acid synthase inhibitor on adipocyte differentiation of mouse 3T3-L1 cells. Acta Pharmacol Sin. 2004;25:1052–7.
Nadler ST, Attie AD. Please pass the chips: genomic insights into obesity and diabetes. J Nutr. 2001;131:2078–81.
Brandacher G, Winkler C, Aigner F, Schwelberger H, Schroecksnadel K, Margreiter R, et al. Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients. Obes Surg. 2006;16:541–8.
Theofylaktopoulou D, Midttun Ø, Ulvik A, Ueland PM, Tell GS, Vollset SE, et al. A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study: determinants of neopterin KTR and kynurenines. Clin Exp Immunol. 2013;173:121–30.
Campbell BM, Charych E, Lee AW, Moller T. Kynurenines in CNS disease: regulation by inflammatory cytokines. Front Neurosci. 2014;8:12.
Wolowczuk I, Hennart B, Leloire A, Bessede A, Soichot M, Taront S, et al. Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. AJP Regul Integr Comp Physiol. 2012;303:R135–43.
Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191–3.
Smith AJ, Stone TW, Smith RA. Neurotoxicity of tryptophan metabolites. Biochem Soc Trans. 2007;35:1287.
Oxenkrug G. Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol. 2013;48:294–301.
Meyramov G, Korchin V, Kocheryzkina N. Diabetogenic activity of xanturenic acid determined by its chelating properties? Transplant Proc. 1998;30:2682–4.
Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, et al. The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity. 2015:23:2066–74.
Maguire D, Talwar D, Shiels PG, McMillan D. The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: a systematic review. Clinical Nutrition ESPEN. 2018;25:8–17.
Wu Y, Dong Y, Atefi M, Liu Y, Elshimali Y, Vadgama JV. Lactate, a neglected factor for diabetes and cancer interaction. Mediators Inflamm. 2016;2016.6456018.
Mandarino LJ, Madar Z, Kolterman OG, Bell JM, Olefsky JM. Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. Am J Physiol. 1986;251:E489e96.
Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS. Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. J Biol Chem. 2003;278(23):21240e6.
Jansson PA, Larsson A, Smith U, Leonnroth P. Lactate release from the subcutaneous tissue in lean and obese men. J Clin Invest. 1994;93(1):240e6.
Lovejoy J, Mellen B, Digirolamo M. Lactate generation following glucose ingestion: relation to obesity, carbohydrate tolerance and insulin sensitivity. Int J Obes. 1990;14(10):843e55.
Cornier MA. A review of current guidelines for the treatment of obesity. Am J Manag Care. 2022;28(15 Suppl):S288-S296.
Pasquali R, Casanueva F, Haluzik M, van Hulsteijn L, Ledoux S, Monteiro MP, et al. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity. Eur J Endocrinol. 2020;182(1):G1-G32.
Lingvay I, Sumithran P, Cohen RV, le Roux CW. Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation. Lancet. 2022;399(10322):394-405.
Dimitriadis G, Mitrou P, Lambadiari V, Maratou E, Raptis SA. Insulin effects in muscle and adipose tissue. Diabetes Res Clin Pract. 2011;93 Suppl 1:S52-9.
Gastaldelli A. Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD? Clin Sci (Lond). 2017;131(22):2701-2704.
Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016;280(5):465-475.
Carpentier AC. 100th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism. Am J Physiol Endocrinol Metab. 20211;320(4):E653-E670.
Leeners B, Geary N, Tobler PN, Asarian L. Ovarian hormones and obesity. Hum Reprod Update. 2017;23(3):300-321.
Cooper AJ, Gupta SR, Moustafa AF, Chao AM. Sex/gender differences in obesity prevalence, comorbidities, and treatment. Curr Obes Rep. 2021;10(4):458-466.
Gambineri A, Pelusi C. Sex hormones, obesity and type 2 diabetes: is there a link? Endocr Connect. 2019;8(1):R1-R9.
Insenser M, Murri M, Del Campo R, Martínez-García MÁ, Fernández-Durán E, Escobar-Morreale HF. Gut microbiota and the polycystic ovary syndrome: Influence of Sex, Sex Hormones, and Obesity. J Clin Endocrinol Metab. 2018;103(7):2552-2562.
Du FM, Kuang HY, Duan BH, Liu DN, Yu XY. Effects of thyroid hormone and depression on common components of central obesity. J Int Med Res. 2019;47(7):3040-3049.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA. The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A systematic review and meta-analysis. Front Immunol. 2019;10:2349.
Walczak K, Sieminska L. Obesity and thyroid axis. Int J Environ Res Public Health. 2021;18(18):9434.
Lochner RH, Delfin L, Nezami BG, Cohen ML, Asa SL, Burguera B, Couce ME. Severe obesity associated with pituitary corticotroph hyperplasia and neoplasia. Endocr Pract. 2023;29(6):471-477.
Gkastaris K, Goulis DG, Potoupnis M, Anastasilakis AD, Kapetanos G. Obesity, osteoporosis and bone metabolism. J Musculoskelet Neuronal Interact. 2020;20(3):372-381.
Rinonapoli G, Pace V, Ruggiero C, Ceccarini P, Bisaccia M, Meccariello L, Caraffa A. Obesity and bone: A complex relationship. Int J Mol Sci. 2021;22(24):13662.
Gu X, Wang L, Liu S, Shan T. Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis. Metabolism. 2023;139:155379.
El.Sabaey RS, Hassan HA, Abbas NAT, Fayed FA. Assessment of possible role of renin angiotensin aldosterone system in obesity: review article. The Egyptian Journal of Hospital Medicine. 2023;91:4828-31.
Litwin M, Kułaga Z. Obesity, metabolic syndrome, and primary hypertension. Pediatr Nephrol. 2021;36(4):825-837.
Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013;9(2):191-200.
Cinti F, Cinti S. The endocrine adipose organ: A system playing a central role in COVID-19. Cells. 2022;11(13):2109.
Nagao M, Lagerstedt JO, Eliasson L. Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells. Diabetol Int. 2022;13(3):471-479.
Tulp OL, Einsteinn GP. Autonomic, immunological and endocrine influences on adipose tissue as an organ. Adv Obes Weight Manag Control. 2021;11(2):48‒58.
Anthony SR, Guarnieri AR, Gozdiff A, Helsley RN, Phillip Owens A, Tranter M. Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis. Clin Sci (Lond). 2019;133(22):2329-2344.
Khanna D, Khanna S, Khanna P, Kahar P, Patel BM. Obesity: A chronic low-grade inflammation and its markers. Cureus. 2022;14(2):e22711.
Lopez-Yus M, Hörndler C, Borlan S, Bernal-Monterde V, Arbones-Mainar JM. Unraveling adipose tissue dysfunction: molecular mechanisms, novel biomarkers, and therapeutic targets for liver fat deposition. Cells. 2024;13(5):380.
Pettersson-Pablo P, Nilsson TK, Breimer LH, Hurtig-Wennlöf A. Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study. Scand J Clin Lab Invest. 2019;79(3):182-187.
Horwitz A, Birk R. Adipose Tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity. Nutrients. 2023;15(15):3445.
Medrano-Bosch M, Simón-Codina B, Jiménez W, Edelman ER, Melgar-Lesmes P. Monocyte-endothelial cell interactions in vascular and tissue remodeling. Front Immunol. 2023;14:1196033.
Garg SS, Kushwaha K, Dubey R, Gupta J. Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions, Diabetes Res Clin Pract. 2023;200:110691.
Richardson VR, Smith K, Carter AM. Adipose tissue inflammation: Feeding the development of type 2 diabetes mellitus. Immunobiology. 2013;218:1497–504.
Zorena K, Jachimowicz-Duda O, Ślęzak D, Robakowska M, Mrugacz M. Adipokines and obesity. Potential link to metabolic disorders and chronic complications. Int J Mol Sci. 2020;21(10):3570.
Johnston EK, Abbott RD. Adipose tissue paracrine-, autocrine-, and matrix-dependent signaling during the development and progression of obesity. Cells. 2023;12(3):407.
Arroyo-Espliguero R, Viana-Llamas MC, Silva-Obregón A, Avanzas P. The role of C-reactive protein in patient risk stratification and treatment. Eur Cardiol. 2021;16:e28.
Salazar J, Martínez MS, Chávez M, Toledo A, Añez R, Torres Y, et al. C-reactive protein: clinical and epidemiological perspectives. Cardiol Res Pract. 2014;2014:605810.
Eder K, Baffy N, Falus A, Fulop AK. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res. 2009;58(11):727-36.
Jiang N, Li Y, Shu T, Wang J. Cytokines and inflammation in adipogenesis: an updated review. Front Med. 2019;13(3):314-329.
Kotur-Stevuljevic J, Simic-Ogrizovic S, Dopsaj V, Stefanovic A, Vujovic A, Ivanic-Corlomanovic T, et al. A hazardous link between malnutrition, inflammation and oxidative stress in renal patients. Clin Biochem. 2012; 45:1202-1205.
Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Stefanović A, Vujović A, et al. PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. Clin Biochem. 2008;41:1067-1073.
Kotur-Stevuljević J, Memon L, Stefanović A, Spasić S, Spasojević-Kalimanovska V, Bogavac-Stanojević N, et al. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. Clin Biochem. 2007;40:181-187.
Ivanisevic J, Kotur-Stevuljevic J, Stefanovic A, Spasic S, Videnovic-Ivanov J, Jelic- Ivanovic Z. Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients. Eur J Clin Invest. 2016;46(5):418-424.
Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2014;16(1):378-400.
Sun Y, Lu Y, Saredy J, Wang X, Drummer Iv C, Shao Y, et al. ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes. Redox Biol. 2020;37:101696.
Di Meo S, Reed TT, Venditti P, Victor VM. Role of ROS and RNS sources in physiological and pathological conditions. Oxid Med Cell Longev. 2016;2016:1245049.
Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180-3.
Sies H. Strategies of antioxidant defense. Eur J Biochem. 1993;215(2):213-9.
Zampelas A, Micha R, editors. Antioxidants in health and disease (1st ed.). CRC Press; 2015. doi: 10.1201/b18539.
Zhang SS, Yang XJ, Ma QH, Xu Y, Chen X, Wang P, Pan CW. Leukocyte related parameters in older adults with metabolically healthy and unhealthy overweight or obesity. Sci Rep. 2021;11(1):4652.
Bilgihan MT, Ciftciler R. The effect of obesity and body mass index on hematologic malignancies. Metab Syndr Relat Disord. 2023;21(7):353-361.
Weinstock A, Moura Silva H, Moore KJ, Schmidt AM, Fisher EA. Leukocyte heterogeneity in adipose tissue, including in obesity. Circ Res. 2020;126:1590-612.
Carvalheira JB, Qiu Y, Chawla A. Blood spotlight on leukocytes and obesity. Blood. 2013;122(19):3263-7.
Kim JA, Park HS. White blood cell count and abdominal fat distribution in female obese adolescents. Metabolism. 2008;57(10):1375-9.
Jeong HR, Lee HS, Shim YS, Hwang JS. Positive associations between body mass index and hematological parameters, including RBCs, WBCs, and Platelet counts, in Korean children and adolescents. Children (Basel). 2022;9(1):109.
Marra A, Bondesan A, Caroli D, Sartorio A. Complete blood count (CBC)-derived inflammation indexes are useful in predicting metabolic syndrome in adults with severe obesity. J Clin Med. 2024; 13(5):1353.
Purdy JC, Shatzel JJ. The hematologic consequences of obesity. Eur J Haematol. 2021;106(3):306-319.
Rodríguez-Rodríguez E, Salas-González MD, Ortega RM, López-Sobaler AM. Leukocytes and neutrophil-lymphocyte ratio as indicators of insulin resistance in overweight/obese school-children. Front Nutr. 2022;8:811081.
Kohsari M, Moradinazar M, Rahimi Z, Najafi F, Pasdar Y, Moradi A, Shakiba E. Association between RBC indices, anemia, and obesity-related diseases affected by body mass index in Iranian Kurdish population: results from a cohort study in western Iran. Int J Endocrinol. 2021;2021:9965728.
Wenzel BJ, Stults HB, Mayer J. Hypoferraemia in obese adolescents. Lancet. 1962;2(7251):327-8.
Christakoudi S, Tsilidis KK, Evangelou E, Riboli E. Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort. BMC Endocr Disord. 2023;23(1):161.
González-Domínguez Á, Visiedo-García FM, Domínguez-Riscart J, González-Domínguez R, Mateos RM, Lechuga-Sancho AM. Iron metabolism in obesity and metabolic syndrome. Int J Mol Sci. 2020;21(15):5529.
Olusi SO. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. Int J Obes Relat Metab Disord. 2002;26(9):1159-64.
Domingo-Ortí I, Lamas-Domingo R, Ciudin A, Hernández C, Herance JR, Palomino-Schätzlein M, Pineda-Lucena A. Metabolic footprint of aging and obesity in red blood cells. Aging (Albany NY). 2021;13(4):4850-80.
Cottam DR, Mattar SG, Barinas-Mitchell E, Eid G, Kuller L, Kelley DE, Schauer PR. The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 2004;14(5):589-600.
Vilahur G, Ben-Aicha S, Badimon L. New insights into the role of adipose tissue in thrombosis. Cardiovasc Res. 2017;113(9):1046-54.
Grandl G, Wolfrum C. Hemostasis, endothelial stress, inflammation, and the metabolic syndrome. Semin Immunopathol. 2018;40(2):215-24.
Singh P, Peterson TE, Barber KR, Kuniyoshi FS, Jensen A, Hoffmann M, et al. Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. Biochem Biophys Res Commun. 2010;392(1):47-52.
Ikeda Y, Tsuchiya H, Hama S, Kajimoto K, Kogure K. Resistin regulates the expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2014;448(2):129-33.
Acquarone E, Monacelli F, Borghi R, Nencioni A, Odetti P. Resistin: a reappraisal. Mech Ageing Dev. 2019;178:46-63.
Corsonello A, Perticone F, Malara A, De Domenico D, Loddo S, Buemi M, et al. Leptin-dependent platelet aggregation in healthy, overweight and obese subjects. Int J Obes Relat Metab Disord. 2003;27(5):566-73.
Bladbjerg EM, Stolberg CR, Juhl CB. Effects of obesity surgery on blood coagulation and fibrinolysis: a literature review. Thromb Haemost. 2020;120(4):579-591.
Afshari A, Ageno W, Ahmed A, Duranteau J, Faraoni D, Kozek-Langenecker S, et al. ESA VTE Guidelines Task Force. European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary. Eur J Anaesthesiol. 2018;35(2):77-83.
Campello E, Zabeo E, Radu CM, Spiezia L, Gavasso S, Fadin M, et al. Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events. Thromb Haemost. 2015;113(1):85-96.
Shen T, Wang J, Yang W, Li L, Qiao Y, Yan X, et al. Hematological parameters characteristics in children with obstructive sleep apnea with obesity. Risk Manag Healthc Policy. 2021;14:1015-23.
Lallukka S, Luukkonen PK, Zhou Y, Isokuortti E, Leivonen M, Juuti A, et al. Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thromb Haemost. 2017;117(2):286-94.
Iglesias Morcillo M, Freuer D, Peters A, Heier M, Meisinger C, Linseisen J. Body mass index and waist circumference as determinants of hemostatic factors in participants of a population-based study. Medicina (Kaunas). 2023;59(2):228.
Braekkan SK, Siegerink B, Lijfering WM, Hansen JB, Cannegieter SC, Rosendaal FR. Role of obesity in the etiology of deep vein thrombosis and pulmonary embolism: current epidemiological insights. Semin Thromb Hemost. 2013;39(5):533-40.
Nkambule BB, Mxinwa V, Nyambuya TM, Dludla PV. The mean platelet volume and atherosclerotic cardiovascular-risk factors in adults with obesity: a systematic review and meta-analysis of observational studies. BMC Nutr. 2022;8(1):47.
Kalyoncu D. Platelet indices in overweight and obese children. Eur J Pediatr. 2023;182(9):3989-95.
Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V. Obesity and dyslipidemia. Metabolism. 2019;92:71-81.
Blüher M. Metabolically Healthy Obesity. Endocrine Rewievs. 2020;41(3):1-16.
Aleksandrova K, Rodrigues CE, Floegel A, Ahrens W. Omics biomarkers in obesity: novel etiological insights and targets for precision prevention. Current Obesity Reports. 2020;9:219–30.
Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, et al. Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry. Hum Mol Genet. 2018;27(20):3641–9.
Fu J, Hofker M, Wijmenga C. Apple or pear: size and shape matter. Cell Metab. 2015;21(4):507–8.
Loos RJF, Janssens A. Predicting polygenic obesity using genetic information. Cell Metab. 2017;25(3):535–43.
Zhou J, Zhang L, Xuan P, Fan Y, Yang L, Hu C, et al. The relationship between famine exposure during early life and body mass index in adulthood: a systematic review and meta-analysis. PLoS One. 2018;13(2):e0192212.
Tobi EW, Slieker RC, Stein AD, Suchiman HE, Slagboom PE, van Zwet EW, et al. Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome. Int J Epidemiol. 2015;44(4):1211–23.
Kaushik P, Anderson JT. Obesity: epigenetic aspects. Biomol Concepts. 2016;7(3):145–55.
Ghosh S, Dent R, Harper ME, Gorman SA, Stuart JS, McPherson R. Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity. BMC Med Genet. 2010;3:56.
Masood A, Benabdelkamel H, Alfadda AA. Obesity proteomics: an update on the strategies and tools employed in the study of human obesity. High Throughput. 2018;7(3):27.
Cominetti O, Nunez Galindo A, Corthesy J, Valsesia A, Irincheeva I, Kussmann M, et al. Obesity shows preserved plasma proteome in large independent clinical cohorts. Sci Rep. 2018;8(1):16981.
Rangel-Huerta OD, Pastor-Villaescusa B, Gil A. Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies. Metabolomics. 2019;15(6):93.
Floegel A, Wientzek A, Bachlechner U, Jacobs S, Drogan D, Prehn C, et al. Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study. Int J Obes. 2014;38(11):1388–96.
Marco-Ramell A, Tulipani S, Palau-Rodriguez M, Gonzalez- Dominguez R, Minarro A, Jauregui O, et al. Untargeted profiling of concordant/discordant phenotypes of high insulin resistance and obesity to predict the risk of developing diabetes. J Proteome Res. 2018;17(7):2307–17.
Kristic J, Vuckovic F, Menni C, Klaric L, Keser T, Beceheli I, et al. Glycans are a novel biomarker of chronological and biological ages. J Gerontol A Biol Sci Med Sci. 2014;69(7):779–89.
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