Zagađivači životne sredine i gojaznost: od uzročno-posledičnih dokaza do otvorenih pitanja

  • Marijana Ćurčić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Javier Esteban Universidad Miguel Hernandez, Instututio Bioingineria
  • Gonca Cakmak Gazi University, Faculty of Pharmacy, Department of Toxicology
  • Ksenija Durgo Sveučilište u Zagrebu, Prehrambeno – biotehnološki fakultet, Laboatorija za biologiju i genetiku mikroorganizama
  • Katarina Baralić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Jovana Živanović Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Djurdjica Marić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Aleksandra Buha Đorđević Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Evica Antonijević Miljaković Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Zorica Bulat Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Biljana Antonijević Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
  • Danijela Djukić Ćosić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za toksikologiju “Akademik Danilo Soldatović”
DOI: https://doi.org/10.5937/arhfarm74-50856
Ključne reči: gojaznost, plastika, metali, POPs, lekovi (otpad), mapa puta

Sažetak


Veza između zagađenja životne sredine i gojaznosti je od velikog značaja, jer razumevanje ovog odnosa može pružiti vredan uvid u složeni set faktora koji doprinose epidemiji gojaznosti. Veruje se da ove hemikalije, zagađujuće supstance, nazvane „obesogeni“, ometaju procese metabolizma lipida, čime podstiču razvoj gojaznosti. Antropogene aktivnosti kao što su industrijalizacija, urbanizacija, poljoprivreda i transport značajno su doprinele zagađenju životne sredine. Shodno tome, najznačajniji identifikovani obesogeni su bisfenol A, koji se nalazi u plastici, ambalaži za hranu i termalnom papiru za račune, ftalati, koji se obično koriste u plastici, proizvodima za ličnu negu i ambalaži za hranu, toksični metal(oid)i, pesticidi, koji se koriste u poljoprivredi, kao i perzistentne organske zagađujuće supstance (POPs) i farmaceutski proizvodi (otpad). Rešavanje pitanja zagađenja životne sredine ne samo da ima potencijal da poboljša kvalitet životne sredine, već i da unapredi javno zdravlje i spreči bolesti povezane sa gojaznošću. Rešavanje uzročno-posledične veze između zagađujućih supstanci i gojaznosti moglo bi biti nova i izazovna mapa puta za zdravstvene profesionalce.

Reference

WHO [Internet]. Noncommunicable diseases: Risk factors; 2024 [cited 2024 May 5]. Available from: https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/ncd-risk-factors.

Verhulst SL, Nelen V, Hond ED, Koppen G, Beunckens C, Vael C, et al. Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life. Environ Health Perspect. 2009;117(1):122-6.

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10.

Đukić-Ćosić D, Baralić K, Javorac D, Bulat Z, Ćurčić M, Antonijević B, et al. Exploring the relationship between blood toxic metal(oid)s and serum insulin levels through benchmark modelling of human data: possible role of arsenic as a metabolic disruptor. Environ Res. 2022;215:114283.

Everett CJ, Medunjanin D, Frithsen IL. Roles of environmental pollution and pesticides in diabetes and obesity: the epidemiological evidence. In: Bagchi D, Nair S, editors. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome; Academic Press; 2018; p. 53-64.

Galbán-Velázquez S, Esteban J, Çakmak G, Artacho-Cordón F, León J, Barril J, et al. Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment. Environ Res. 2021;195:110764.

Huđek Turković A, Matovinović M, Žuna K, Škara L, Kazazić S, Bačun-Družina V, Durgo K. Association of vitamins D, B9 and B12 with obesity-related diseases and oral microbiota composition in obese women in Croatia. Food Technol Biotechnol. 2022;60(2):135-44.

Kelishadi R, Poursafa P, Jamshidi F. Role of environmental chemicals in obesity: a systematic review on the current evidence. J Environ Public Health. 2013;2013:896789.

Smith K, Qu W, Ren X, Wang Y. Does Pollution Exacerbate Obesity Risks? A Systematic Review and Meta‐analysis. FASEB J. 2015;29:736-34.

La Merrill M, Birnbaum LS. Childhood obesity and environmental chemicals. Mt Sinai J Med. 2011;78(1):22-48.

Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, et al. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol. 2022;199:115012.

Aaseth J, Javorac D, Djordjevic AB, Bulat Z, Skalny AV, Zaitseva IP, et al. The role of persistent organic pollutants in obesity: a review of laboratory and epidemiological studies. Toxics. 2022;10(2):65.

An R, Ji M, Yan H, Guan C. Impact of ambient air pollution on obesity: a systematic review. Int J Obes. 2018;42(6):1112-26.

Baralić K, Živančević K, Božić D, Jennen D, Djordjevic AB, Miljaković EA, Đukić-Ćosić D. Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. Biocell. 2022;46(2):519.

Buha A, Manic L, Maric D, Tinkov A, Skolny A, Antonijevic B, Hayes AW. The effects of endocrine-disrupting chemicals (EDCs) on the epigenome-A short overview. Toxicol Res Appl. 2022;6:23978473221115817.

Entezari B, Bozdağ D, Gürer-Orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul J Pharm. 2022;52(2):215-25.

Iughetti L, Lucaccioni L, Predieri B. Childhood obesity and environmental pollutants: a dual relationship. Acta Biomed. 2015;86(1):5-16.

Wang Y, Hollis‐Hansen K, Ren X, Qiu Y, Qu WJ. Do environmental pollutants increase obesity risk in humans?. Obes Rev. 2016;17(12):1179-97.

Khalil WJ, Akeblersane M, Khan AS, Moin AS, Butler AE. Environmental pollution and the risk of developing metabolic disorders: obesity and diabetes. Int J Mol Sci. 2023;24(10):8870.

Le Magueresse-Battistoni B, Vidal H, Naville D. Environmental pollutants and metabolic disorders: the multi-exposure scenario of life. Front Endocrinol. 2018;9:582.

Nappi F, Barrea L, Di Somma C, Savanelli MC, Muscogiuri G, Orio F, Savastano S. Endocrine aspects of environmental “obesogen” pollutants. Int J Environ Res Public Health. 2016;13(8):765.

Nicolaidis S. Environment and obesity. Metabolism. 2019;100:153942.

Zhan J, Liang Y, Liu D, Ma X, Li P, Zhai W, et al. Pectin reduces environmental pollutant-induced obesity in mice through regulating gut microbiota: A case study of p, p′-DDE. Environ Int. 2019;130:104861.

Panieri E, Baralic K, Djukic-Cosic D, Buha Djordjevic A, Saso L. PFAS molecules: a major concern for the human health and the environment. Toxics. 2022;10(2):44.

Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, et al. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022;199:115015.

Bisht A, Kamboj N, Kamboj V, Bisht A. A review on the role of emerging anthropogenic activities in environmental degradation and emphasis on their mitigation. Arch Agric Environ Sci. 2020;5(3):419-25.

European Environment Agency (EEA) [Internet]. Harm to human health from air pollution in Europe: burden of disease; 2023 [cited 2024 May 5]. Avalable from: https://www.eea.europa.eu/publications/harm-to-human-health-from-air-pollution.

WHO [Internet]. Drinking-water; 2023 [cited 2024 May 5]. Available from: https://www.who.int/news-room/fact-sheets/detail/drinking-water.

Tinkov AA, Aschner M, Ke T, Ferrer B, Zhou JC, Chang JS, et al. Adipotropic effects of heavy metals and their potential role in obesity. Fac Rev. 2021;10:32.

Wang X, Mukherjee B, Park SK. Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among US adults in NHANES 2003–2014. Environ Int. 2018;121:683-94.

Baralić K, Živančević K, Bozic D, Đukić-Ćosić D. Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge. Food Chem Toxicol. 2023;172:113582.

Li X, Brejnrod AD, Ernst M, Rykær M, Herschend J, Olsen NM, et al. Heavy metal exposure causes changes in the metabolic health-associated gut microbiome and metabolites. Environ Int. 2019;126:454-67.

Noppakun K, Juntarawijit C. Association between pesticide exposure and obesity: A cross-sectional study of 20,295 farmers in Thailand. F1000Research. 2021;10:445.

Sharma K, Kaushik G. Urbanization and pharmaceutical waste: an upcoming environmental challenge. In: Kateja A, Jain R, editors. Urban Growth and Environmental Issues in India. Singapore: Springer; 2021; p. 287-300.

Yang C, Kong AP, Cai Z, Chung AC. Persistent organic pollutants as risk factors for obesity and diabetes. Curr Diab Rep. 2017;17(12):132.

Objavljeno
2024/06/28
Broj časopisa
Vol. 74 Br. Notebook 3 (2024): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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