KATP channels and cardioprotection

Eylem Taskin; Natalie Samper; Hua-Qian Yang; Tomoe Y Nakamura; Ravichandran Ramasamy; William Coetzee

doi:10.5937/arhfarm74-51604

Eylem Taskin Adiyaman University, Department of Physiology
Natalie Samper Adiyaman University, Department of Physiology
Hua-Qian Yang Soochow University, Cyrus Tang Medical Institute
Tomoe Y Nakamura Wakayama Medical University, Department of Pharmacology
Ravichandran Ramasamy NYU Grossman School of Medicine, Department of Medicine and Biochemistry and Molecular Pharmacology
William Coetzee NYU Grossman School of Medicine, Department of Pathology, Physiology and Neuroscience, and Biochemistry

DOI: https://doi.org/10.5937/arhfarm74-51604

Ključne reči: KATP kanali, otvarači kalijumskih kanala, kardioprotekcija, ishemija, reperfuzija, prekondicija

Sažetak

U ovom preglednom radu razmatraju se ATP-osetljivi kalijumski (K_ATP) kanali, koji povezuju unutarćelijski energetski metabolizam sa ćelijskom električnom aktivnošću i igraju ključnu ulogu u različitim fiziološkim procesima, posebno u pankreasu i kardiovaskularnom sistemu. K_ATP kanali se otvaraju kada se nivo ATP smanji tokom metaboličkog stresa, kao što je ishemija, pomažući tako u zaštiti srca od oštećenja održavanjem membranskog potencijala i sprečavanjem preopterećenja kalcijumom. Ovi kanali se nalaze u različitim tipovima ćelija širom kardiovaskularnog sistema, utičući na vaskularni tonus i ekscitabilnost srca. U radu se naglašava potreba za daljim istraživanjem specifične ekspresije podjedinica K_ATP kanala kod ljudi i posledica ishemijskih događaja na njihovu funkcionalnost. Takođe, istražuje se međusobni odnos glikolize i K_ATP kanala i sugeriše se da glikolitički ATP može modulisati aktivnost K_ATP kanala, pri čemu se naglašavaju kardioprotektivni efekti tokom ishemijskih događaja. Uočen je potencijal otvarača K_ATP kanala (KCOs) kao terapijskih agenasa za ishemijsku bolest srca, posebno u poboljšanju ishoda kod pacijenata podvrgnutim kardiološkim zahvatima. I dalje postoje izazovi u razvoju specifičnih KCOs sa minimalnim nuspojavama, ali napredak u preciznoj medicini može u budućnosti poboljšati ciljane terapije. Imajući sve ovo u vidu, K_ATP kanali predstavljaju obećavajuće mete za unapređenje kardiovaskularnog zdravlja.

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KATP kanali i kardioprotekcija

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