PSYCHIATRIC NOSOLOGY IN THE LIGHT OF EVOLUTION

Psychiatry and evolution

  • Milica Nešić Clinic for Psychiatry, Clinical Center of Serbia
Keywords: natural selection, trade-off, schizophrenia, psychosis

Abstract


Evolution is under-studied in medicine, psychology, and neuroscience. For this reason, these disciplines are deprived of the important insights about the human brain. Our species has had a long and complex history which has shaped the current form and function of out mental apparatus. Indeed, many of our brain s features make sense only when compared to other animal species, especially those with which we share ancestry. 

This paper has two goals. The first one is to lay out the basic principles of evolution which have contributed to our species vulnerability to psychiatric disorders. The second goal is to consider the validity of current psychological concepts and classifications of psychiatric disorders in light of the most recent findings from evolutionary biology and neuroscience. 

References

1.     Cisek P, Hayden BY. Neuroscience needs evolution. Philos Trans R Soc Lond B Biol Sci. 2022 Feb 14;377(1844):20200518.

2.     Varki A. Nothing in medicine makes sense, except in the light of evolution. J Mol Med (Berl). 2012 May;90(5):481-94. 

3.     The Nobel Assembly at the Karolinska Institute (3. oktobar 2022) Press release: The Nobel Prize in Physiology or Medicine. Nobelprize.org. https://www.nobelprize.org/uploads/2022/10/press-medicine2022.pdf"> style="font-family: 'Times New Roman', serif;">>

4.     Green RE, et al. A draft sequence of the Neandertal genome. Science. 2010 May 7;328(5979):710-722.

5.     Boyd RSilk JBHow Humans Evolved. W. W. Norton & Company, New York, NY1997.

6.     Garland T Jr. Trade-offs. Curr Biol. 2014 Jan 20;24(2):R60-R61.

7.     Sherwood C, Gómez-Robles A. Brain plasticity and human evolution. Ann. Rev. Anthropol. 2017; 46: 399–419.

8.     Nesic MJ, Stojkovic B, Maric NP. On the origin of schizophrenia: Testing evolutionary theories in the post-genomic era. Psychiatry Clin Neurosci. 2019 Dec;73(12):723-730.

9.     Matheson SL, Shepherd AM, Pinchbeck RM, Laurens KR, Carr VJ. Childhood adversity in schizophrenia: A systematic meta-analysis. Psychol. Med. 2013; 43: 225–238.

10.  Infurna MR, Reichl C, Parzer P, Schimmenti A, Bifulco A, Kaess M. Associations between depression and specific childhood experiences of abuse and neglect: A meta-analysis. J. Affect. Disord. 2016; 190: 47–55.

11.  Neniskyte U, Gross CT. Errant gardeners: Glial-cell-dependent synaptic pruning and neurodevelopmental disorders. Nat. Rev. Neurosci. 2017; 18: 658–670.

12.  Avena-Koenigsberger A, Misic B, Sporns O. Communication dynamics in complex brain networks. Nat Rev Neurosci. 2017 Dec 14;19(1):17-33.

13.  Dobzhansky, T. Nothing in Biology Makes Sense except in Light of Evolution. mar. 1973. In. The American Biology Teacher, 125-129.

14.  Simakov O, et al. Hemichordate genomes and deuterostome origins. Nature. 2015 Nov 26;527(7579):459-65.

15.  Pollard KS, Salama SR, Lambert N et al. An RNA gene expressed during cortical development evolved rapidly in humans. Nature 2006; 443: 167–172.

16.  Levchenko A, Kanapin A, Samsonova A, Gainetdinov RR. Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development. Genome Biol. Evol. 2018; 10: 166–188.

17.  Capra JAErwin GDMckinsey GRubenstein JLRPollard KSMany human accelerated regions are developmental enhancersPhilos. Trans. R. Soc. B Biol. Sci. 201336820130025.

18.  Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT. Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions. Mol. Biol. Evol. 2015; 32: 1148–1160.

19.  Suzuki IKGacquer DVan Heurck R et al. Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/NOTCH regulationCell 201817313701384.

20.  Fiddes IT, Lodewijk GA, Mooring M et al. Human-specific NOTCH2NL genes affect NOTCH signaling and cortical neurogenesis. Cell 2018; 173: 1356–1369.

21.  Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. J. Comp. Neurol. 2001; 436: 167–181.

22.  Song JHT, Lowe CB, Kingsley DM. Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia. Am. J. Hum. Genet. 2018; 103: 421–430.

23.  van den Heuvel MP, Scholtens LH, de Lange SC, Pijnenburg R, Cahn W, van Haren NEM, Sommer IE, Bozzali M, Koch K, Boks MP, Repple J, Pievani M, Li L, Preuss TM, Rilling JK. Evolutionary modifications in human brain connectivity associated with schizophrenia. Brain. 2019 Dec 1;142(12):3991-4002.

24.  Pryluk R, Kfir Y, Gelbard-Sagiv H, Fried I, Paz R. A Tradeoff in the Neural Code across Regions and Species. Cell. 2019 Jan 24;176(3):597-609.e18. 

25.  Gómez-Robles A, Hopkins WD, Schapiro SJ, Sherwood CC. Relaxed genetic control of cortical organization in human brains compared with chimpanzees. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14799-804.

26.  Ripke S, Neale BM, Corvin A et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014; 511: 421–427.

27.  Brainstorm Consortium et al. Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395):eaap8757.

28.  Sporns O. The complex brain: connectivity, dynamics, information. Trends Cogn Sci. 2022 oct in press. 

29.  National Institute of Mental Health (6. oktobar 2022). RdoC Constructs: Attention https://www.nimh.nih.gov/research/research-funded-by-nimh/rdoc/constructs/attention"> style="font-family: 'Times New Roman', serif;">>

30.  Krauzlis RJ, Bollimunta A, Arcizet F, Wang L. Attention as an effect not a cause. Trends Cogn Sci. 2014 Sep;18(9):457-64.

31.  Noudoost B, Moore T. The role of neuromodulators in selective attention. Trends Cogn Sci. 2011 Dec;15(12):585-91.

Published
2023/02/11
How to Cite
Nešić, M. (2023). PSYCHIATRIC NOSOLOGY IN THE LIGHT OF EVOLUTION. Engrami, 44(2). https://doi.org/10.5937/engrami44-40557
Section
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