Iritabilnost kod dece i adolescenata: Savremeni pogledi i kliničke implikacije

  • Dejan Stevanović Clinic for Neurology and Psychiatry for Children and Youth
  • Teodor Stevanović
Ključne reči: psihopatologija, transdijagnostički, frustracija, ljutnja, mladi

Sažetak


Iako se patološka razdražljivost dugo proučava, intenzivna istraživanja poslednjih dvadesetak godina donela su značajne nalaze o njenoj etiologiji i potencijalnim terapijama. Ovaj pregled prikazuje savremena shvatanja, dijagnostičke aspekte, neuropsihobiološke karakteristike i lečenje razdražljivosti kod dece i adolescenata. Razdražljivost se danas shvata kao povećana sklonost ka ljutnji koja se stabilno ispoljava tokom vremena. Iako sama po sebi nije poremećaj, razdražljivost je kardinalni simptom poremećaja protivljenja i prkosa sa hroničnom razdražljivošću-ljutnjom. Prisutna je i kao pridruženi simptom kod različitih internalizujućih i eksternalizujućih poremećaja, a posebno se povezuje sa depresijom, anksioznim poremećajima, autizmom i poremećajem sa deficitom pažnje i hiperaktivnošću. Pretpostavlja se da nastaje usled smanjene tolerancije na frustraciju i sniženog praga za percepciju spoljnih stimulansa kao pretećih, kao i da je nasledna odlika značajno zavisna od sredinskih uticaja. Lečenje se bazira na farmakološkim, nefarmakološkim i kombinovanim tretmanima, pri čemu su antipsihoticima druge generacije dokazano najefikasniji. Šire shvatanje razdražljivosti kao složenog transdijagnostičkog, psihopatološkog fenotipa raspoloženja, kognicije i ponašanja, a zajedničkog imenitelja različitih poremećaja, ima važne kliničke implikacije, naročito za rano prepoznavanje, pravilno dijagnostikovanje i efikasno lečenje.  

Biografija autora

Dejan Stevanović, Clinic for Neurology and Psychiatry for Children and Youth

child psychiatry

child psychopathology

cognitive neuropsychiatry

Reference

Toohey MJ, DiGiuseppe R. Defining and measuring irritability: Construct clarification and differentiation. Clin Psychol Rev 2017;53:93–108.

World Health Organization. Clinical descriptions and diagnostic requirements for ICD-11 mental, behavioural and neurodevelopmental disorders. World Health Organization; 2024. https://www.who.int/publications/i/item/9789240077263

Vidal-Ribas P, Brotman MA, Valdivieso I, Leibenluft E, Stringaris A. The status of irritability in psychiatry: a conceptual and quantitative review. J Am Acad Child Adolesc Psychiatry 2016; 55(7):556-570.

Mikita N, Stringaris A. Mood dysregulation. Eur Child Adolesc Psychiatry 2013;22:11-6.

Stringaris A, Vidal‐Ribas P, Brotman MA, Leibenluft E. Practitioner Review: Definition, recognition, and treatment challenges of irritability in young people. J Child Psychol Psychiatry 2018; 59(7):721–39.

Correll CU, Blader JC. Antipsychotic use in youth without psychosis: a double-edged sword. JAMA psychiatry. 2015;72(9):859-60.

Brotman MA, Kircanski K, Stringaris A, Pine DS, Leibenluft E. Irritability in youths: A translational model. Am J Psychiatry. 2017;174(6):520-32.

American Psychiatric Association DS. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American psychiatric association; 2013.

World Health Organization. ICD-11: International classification of diseases (11th revision). 2022, https://icd.who.int/

Bell E, Boyce P, Porter RJ, Bryant RA, Malhi GS. Irritability in mood disorders: neurobiological underpinnings and implications for pharmacological intervention. CNS drugs 2021; 35(6):619-41.

Stringaris, A. Definition and presentation of Irritability. Multi-Stakeholder Meeting on Paediatric Irritability, 18-19 March 2024, Nice, France

Evans SC, Burke JD, Roberts MC, Fite PJ, Lochman JE, De La Peña FR, et al. Irritability in child and adolescent psychopathology: An integrative review for ICD-11. Clin Psychol Rev 2017; 53:29–45.

Leibenluft E. Pediatric irritability: a systems neuroscience approach. Trends Cogn Sci 2017; 21(4):277-89.

Evans SC, Karlovich AR, Khurana S, Edelman A, Buza B, Riddle W, et al. Evidence Base Update on the Assessment of Irritability, Anger, and Aggression in Youth. J Clin Child Adolesc Psychol 2024; 53(2):277–308.

Carlson GA, Singh MK, Amaya-Jackson L, Benton TD, Althoff RR, Bellonci C, et al. Narrative Review: Impairing Emotional Outbursts: What They Are and What We Should Do About Them. J Am Acad Child Adolesc Psychiatry 2023;62(2):135–50.

Leibenluft E, Allen LE, Althoff RR, Brotman MA, Burke JD, Carlson GA, et al. Irritability in Youths: A Critical Integrative Review. Am J Psychiatry 2024; 181(4):275–90.

Saatchi B, Olshansky EF, Fortier MA. Irritability: A concept analysis. Int J Mental Health Nurs 2023; 32(5):1193-210.

Krieger FV, Leibenluft E, Stringaris A, Polanczyk GV. Irritability in children and adolescents: past concepts, current debates, and future opportunities. Rev Bras Psiquiatr 2013; 35:S32–S39.

Copeland WE, Brotman MA, Costello EJ. Normative irritability in youth: developmental findings from the Great Smoky Mountains Study. J Am Acad Child Adolesc Psychiatry 2015; 54(8): 635-42.

Silver J, Sorcher L, Carlson GA, Dougherty LR, Klein DN. Irritability across adolescence: Examining longitudinal trajectory, stability, and associations with psychopathology and functioning at age 18. J Affect Dis 2024;354:611–8.

Moreno, C. Setting the scene and defining unmet needs. Multi-Stakeholder Meeting on Paediatric Irritability, 18-19 March 2024, Nice, France

Evans SC, Corteselli KA, Edelman A, Scott H, Weisz JR. Is irritability a top problem in youth mental health care? A multi-informant, multi-method investigation. Child Psychiatr Human Devel 2023;54(4):1027-41.

Stringaris A, Goodman R. Three dimensions of oppositionality in youth. J Child Psychol Psychiatry 2009;50:216-223.

Stringaris A, Cohen P, Pine DS, Leibenluft E. Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study. Am J Psychiatry 2009; 166(9):1048–54.

Orri M, Galera C, Turecki G, Forte A, Renaud J, Boivin M, et al. Association of Childhood Irritability and Depressive/Anxious Mood Profiles With Adolescent Suicidal Ideation and Attempts. JAMA Psychiatry 2018;75(5):465.

Pickles A, Aglan A, Collishaw S, Messer J, Rutter M, Maughan B. Predictors of suicidality across the life span: the Isle of Wight study. Psychol med 2010;40(9):1453-66.

Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG, Arnold LE. A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC medicine. 2012 Dec;10:1-5.

Simonoff E, Jones CR, Pickles A, Happé F, Baird G, Charman T. Severe mood problems in adolescents with autism spectrum disorder. Journal of Child Psychology and Psychiatry. 2012 Nov;53(11):1157-66.

Krebs G, Bolhuis K, Heyman I, Mataix-Cols D, Turner C, Stringaris A. Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome. J Child Psychol Psychiatr 2013;54(3):313–322.

Leibenluft E, Avenevoli S. Paper presented at: National Institute of Mental Health workshop Childhood Irritability and the Pathophysiology of Mental Illness 2014; Bethesda, MD: National Institute of Mental Health.

Quiñones‐Camacho LE, Fishburn FA, Camacho MC, Hlutkowsky CO, Huppert TJ, Wakschlag LS, Perlman SB. Parent–child neural synchrony: a novel approach to elucidating dyadic correlates of preschool irritability. J Child Psychol Psychiatry 2020; 61(11):1213-23.

Elvin OM, Modecki KL, Waters AM. An Expanded Conceptual Framework for Understanding Irritability in Childhood: The Role of Cognitive Control Processes. Clin Child Fam Psychol Rev 2024; 27(2):381-406.

Nielsen AN, Wakschlag LS, Norton ES. Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC. Neurosci Biobehav Rev 2021; 129: 231-44.

Roberson-Nay R, Leibenluft E, Brotman MA, et al. Longitudinal stability of genetic and environmental influences on irritability: from childhood to young adulthood. Am J Psychiatry 2015;172:657-664.

Stringaris A, Zavos H, Leibenluft E, Maughan B, Eley TC. Adolescent irritability: phenotypic associations and genetic links with depressed mood. Am J Psychiatry 2012;169:47-54.

Savage J, Verhulst B, Copeland W, Althoff RR, Lichtenstein P, Roberson- Nay R. A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms. J Am Acad Child Adolesc Psychiatry 2015;54:377-384.

Becht AI, Prinzie P, Dekovi_c M, et al: Child personality facets and overreactive parenting as predictors of aggression and rulebreaking trajectories from childhood to adolescence. Dev Psychopathol 2016; 28:399–413

Cortese S, Purper-Ouakil D, Apter A, et al. Psychopharmacology in children and adolescents: unmet needs and opportunities. Lan Psychiatr 2024; 11(2):143-54.

Breaux R, Baweja R, Eadeh HM, et al. Systematic review and meta-analysis: pharmacological and nonpharmacological interventions for persistent nonepisodic irritability. J Am Acad Child Adolesc Psychiatry 2023; 62(3):318-34.

Krieger FV, Pheula GF, Coelho R, et al. An open-label trial of risperidone in children and adolescents with severe mood dysregulation. J Child Adolesc Psychopharmacol 2011;21:237-243.

Scotto Rosato N, Correll CU, Pappadopulos E, et al. Treatment of maladaptive aggression in youth: CERT guidelines II. Treatments and ongoing management. Pediatrics 2012; 129(6):e1577-86.

de Pablo GS, Jordá CP, Vaquerizo-Serrano J, et al. Systematic review and meta-analysis: efficacy of pharmacological interventions for irritability and emotional dysregulation in autism spectrum disorder and predictors of response. J Am Acad Child Adolesc Psychiatry 2023; 62(2):151-68.

Choi H, Kim JH, Yang HS, et al. Pharmacological and non-pharmacological interventions for irritability in autism spectrum disorder: a systematic review and meta-analysis with the GRADE assessment. Mol Autism 2024; 15(1):7.

Shaw P, Stringaris A, Nigg J, Leibenluft E. Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 2014;171: 276-293.

Fernandez de la Cruz L, Simonoff E, McGough JJ, Halperin JM, Arnold LE, Stringaris A. Treatment of children with attention-deficit/hyperactivity disorder (ADHD) and irritability: results from the multimodal treatment study of children with ADHD (MTA). J Am Acad Child Adolesc Psychiatry. 2015;54:62-70.e3.

Cortese, S. Treatments for emotional dysregulation in ADHD. Multi-Stakeholder Meeting on Paediatric Irritability, 18-19 March 2024, Nice, France

Kim S, Boylan K. Effectiveness of antidepressant medications for symptoms of irritability and disruptive behaviors in children and adolescents. J Child Adolesc Psychopharmacol 2016; 26:694–704.

Towbin K, Vidal-Ribas P, Brotman MA, et al: A double-blind randomized placebo-controlled trial of citalopram adjunctive to stimulant medication in youth with chronic severe irritability. J Am Acad Child Adolesc Psychiatry 2020; 59:350–361

Dickstein DP, Towbin KE, Van Der Veen JW, et al. Randomized doubleblind placebo-controlled trial of lithium in youths with severe mood dysregulation. J Child Adolesc Psychopharmacol 2009;19:61-73.

Blader JC, Schooler NR, Jensen PS, Pliszka SR, Kafantaris V. Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. Am J Psychiatry 2009;166:1392-1401

Sukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral interventions for anger, irritability, and aggression in children and adolescents. J Child Adolesc Psychopharmacol 2016; 26:58–64.

Ćirović N, Stevanovic D, Nguyen HTM, Meszaros ZS, Kerekes N. Thought and mood/arousal disturbances as central broad dimensions in youth psychopathology: A network analysis. Neuroscience App 2024; 3(Suppl 1): 103951.

Caspi A, Houts RM, Fisher HL, Danese A, Moffitt TE. The general factor of psychopathology (p): Choosing among competing models and interpreting p. Clin Psychol Sci 2024;12(1):53-82.

Kessel EM, Frost A, Goldstein BL, Black SR, Dougherty LR, Carlson GA, Klein DN. Developmental pathways from preschool irritability to multifinality in early adolescence: The role of diurnal cortisol. Psychol Med 2021; 51(5):761-9.

Naim R, Goodwin MS, Dombek K, Revzina O, Agorsor C, Lee K, Zapp C, Freitag GF, Haller SP, Cardinale E, Jangraw D. Cardiovascular reactivity as a measure of irritability in a transdiagnostic sample of youth: Preliminary associations. International Journal of Method Psychiatr Res 2021; 30(4):e1890.

Objavljeno
2024/11/10
Kako citirati
Stevanović, D., & Stevanović, T. (2024). Iritabilnost kod dece i adolescenata: Savremeni pogledi i kliničke implikacije. Engrami, 46(1). https://doi.org/10.5937/engrami46-52625
Broj časopisa
Rubrika
PREGLEDNI RADOVI