The outcome in relation to the treatment of patients with acute ST elevated myocardial infarction in whom more than 12 hours and less than 48 hours have passed since the onset of symptoms.

Treatment in relation to the treatment of patients with acute STEMI

  • Vladimir Ivanović Univerzitet u Novom Sadu, Medicinski fakultet
  • Jelena Grgur Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad, Srbija
  • Dragana Dabović Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija
  • Milovan Petrović 1 Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija; 2 Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
  • Anastazija Stojšić-Milosavljević 1 Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija; 2 Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
  • Marija Bjelobrk 1 Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija; 2 Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
  • Milenko Čanković 1 Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija; 2 Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
  • Maja Stefanović 1 Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija; 2 Univerzitet u Novom Sadu, Medicinski fakultet, Novi Sad, Srbija
Keywords: Acute myocardial infarction, primary percutaneous coronary intervention, medical treatment, outcome

Abstract


Introduction. Patients in whom more than 12 hours have passed since the onset of symptoms, according to anamnestic data, represent late presenters of acute myocardial infarction

Method. The study included 130 patients who were admitted because of the  acute STEMI from January to December  2017. Of these, 109 patients were treated with pPCI, while 21 patients were treated conservatively. Correlation was made between treatment outcomes, in-hospital mortality, one-year survival in relation to treatment, as well as risk factors and comorbidities.

Results. There was a statistically significant difference in outcome compared to treatment (x2 = 7.119, p = 0.017). 8.3% of patients treated with pPCI were died, while 28.6% of patients treated conservatively were died.  Statistically significant difference (t = 9.385; p = 0.005) was observed in terms of treatment outcome and diabetes mellitus.

Conclusion. Clinical, hemodynamic status and the presence of life-threatening arrhythmias should be considered when making treatment decisions.

Author Biographies

Jelena Grgur, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad, Srbija

medical doctor

Dragana Dabović, Institut za kardiovaskularne bolesti Vojvodine, Klinika za kardiologiju, Sremska Kamenica, Srbija

lekar na specijalizaciji

References

1. White HD, Chew DP. Acute myocardial infarction. Lancet.2008; 372(9638): 570–84. doi:10.1016/S0140-6736(08)61237-4. PMC 1931354. PMID 18707987.
2. Ibanez B, James S, Agewall S, Antunes M, Bucciarelli-Ducci C, Bueno H. 2017 ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-segment Elevation: The Task Force for the Management of Acute Myocardial Infarction in Patients Presenting With ST-segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177. doi: 10.1093/eurheartj/ehx393.
3. Jäger B, Farhan S, Rohla M, Christ G, Podczeck-Schweighofer A, Schreiber W et al; Vienna STEMI Registry Group. Clinical predictors of patient related delay in the VIENNA ST-elevation myocardial infarction network and impact on long-term mortality. Eur Heart J Acute Cardiovasc Care. 2017;6(3):254-61.
4. Schömig A, Mehilli J, Antoniucci D, Ndrepepa G, Markwardt C, Di Pede F et al . Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. JAMA. 2005;293(23):2865-72.
5. Sim DS, Jeong MH, Ahn Y, Kim YJ, Chae SC, Hong TJ, et al. Benefit of Percutaneous Coronary Intervention in Early Latecomers With Acute ST segment Elevation Myocardial Infarction. Am J Cardiol. 2012;110(9):1275-81.
6. Dharma S, Andriantoro H, Purnawan I, Dakota I, Basalamah F, Hartono B et al. Characteristics, treatment and in-hospital outcomes of patients with STEMI in a metropolitan area of a developing country: an initial report of the extended Jakarta Acute Coronary Syndrome registry. BMJ Open. 2016 ;6(8):e012193.
7. Cerrato E, Forno D, Ferro S, Chinaglia A. Characteristics, in-hospital management and outcome of late acute ST-elevation myocardial infarction presenters.
J Cardiovasc Med (Hagerstown). 2017;18(8):567-71.
8. Elmariah S, Smith SC, Fuster V. Late medical versus interventional therapy for stable ST-segment elevation myocardial infarction. Nat Clin Pract Cardiovasc Med. 2008; 5:42–52.
Published
2020/12/22
Section
Review articles