MARKERI UPALE I IMUNOLOŠKE KOMPETENCIJE: PROCENA U RANOJ POSTOPERATIVNOJ FAZI KADIOHIRURGIJE KOJE UKLJUČUJE EKSTRAKORPOREALNU CIRKULACIJU

Markeri inflamacije i imunološke kompetencije

DOI: https://doi.org/10.5937/jomb0-56889
Ključne reči: ekstrakorporalna cirkulacija; C-reaktivni protein; serumski amiloid A; monociti

Sažetak


Uvod: Da bismo stekli uvid u ulogu i važnost upalnih i imunoloških markera u sveobuhvatnoj proceni imunološkog odgovora pacijenta na hirurški zahvat, naša studija se fokusirala na istraživanje preoperativne i postoperativne dinamike serumskih nivoa SAA, CRP i udela HLA-DR+CD14+monocita, CD14+ monocita, and pro-inflammatornih monocita CD16+CD14+ kod pacijenata koji su bili podvrgnuti operaciji srca uz pomoć ekstrakorporalne cirkulacije (on-pump).

Metode: U Centru za srce Kliničkog centra Univerziteta u Sarajevu provedena je opservacijska, prospektivna studija na 53 pacijenta podeljena u 3 starosne grupe: 50 – 59, 60 – 69 i 70 – 80 godina. Nivoi CRP i SAA u serumu su kvantitativno određeni imunonefelometrijom. Istovremeno je primenjena tehnologija protočne citometrije za merenje udela HLA-DR+CD14+monocita, CD14+ monocita, and pro-inflammatornih monocita CD16+CD14+

Rezultati: Izmerene vrednosti CRP, SAA, udeo monocita CD14+ monocita i udeo proinflamatornih monocita CD16+CD14+ su značajno povećane postoperativno u odnosu na preoperativne vrednosti (p<0,05). Udeo HLA-DR+CD14+monocita je niži postoperativno u odnosu na preoperativne vrednosti (p<0,001). Nadalje, nema značajnih polnih razlika u preoperativnim ili postoperativnim parametrima (p>0,05), sa izuzetkom preoperativnog udela monocita (CD14+) (p<0,05). Analiza starosnih razlika ukazuje da među definisanim starosnim grupama nije bilo značajnih promena u posmatranim preoperativnim i postoperativnim parametrima (p>0,05).

Zaključak: Rano praćenje upalnih i imunoloških markera u postoperativnoj fazi moglo bi biti korisno za zdravstvene profesionalce za provođenje brzih intervencija usmjerenih na ublažavanje negativnih ishoda.

Reference

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Objavljeno
2025/05/27
Broj časopisa
Vol. 44 Br. 8 (2025): Journal of Medical Biochemistry
Rubrika
Original paper

Sva prava zadržana (c) 2025 Selma Mutevelić, Lejla Bajramović-Omeragić, Merima Šehić, Sumejja Baljević-Spahić, Belma Pehlivanović Kelle, Ermin Begović, Berina Hasanefendić, Ermina Mujičić, Marina Delić-Šarac, Drago Batinić

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