EuReCa_Serbia 2014-2021. Epidemiological analysis of out-of-hospital cardiac arrest - the influence of reactive time on the success of resuscitation
Abstract
The aim of this study is to analyze the basic epidemiological data related to OHCA and the impact of time intervals during the care of OHCA patients on their survival. Materials and Methods: Epidemiological data, data related to time intervals during the response and care process of OHCA patients, as well as outcome data for these patients, were analyzed in seven municipalities in Serbia. Data were collected as part of the EuReCa_Srbija program during the period from October 1, 2014, to December 31, 2021. Results: The overall annual incidence of recorded OHCA in the studied area was 137.43/100,000 inhabitants, while the annual incidence of initiating CPR measures was 50.16/100,000. In the group of patients with initiated CPR measures, a bystander initiated CPR in 16.98% of cases (annual incidence 8.52/100,000). Return of spontaneous circulation (ROSC) at the scene was recorded in 18.71% of cases with an annual incidence of 9.38/100,000, while in the same group, 15.49% of patients with ROSC were admitted to the hospital (annual incidence 7.77/100,000). The median response time of emergency medical services was 9.0 (IQR 5.0-17.0) minutes, the time from achieving ROSC to hospital arrival was 17.0 (IQR 12.0-27.0) minutes, and the time from departure from the cardiac arrest scene to hospital arrival was 9.5 (IQR 5.0-17.0) minutes. The cumulative proportion of ROSC was 50% after 5.6 kilometers traveled, or 5 minutes from the emergency call. ROSC at the scene was not recorded after 20 minutes from the emergency call, or after 11.2 kilometers traveled from the call reception to the scene. Conclusion: The incidence of OHCA in Serbia is comparable to that in other countries, with room for improvement in terms of greater layperson involvement in initiating CPR measures. The time intervals during the EMS response and care process for OHCA patients are longer compared to reports from other countries, indicating the need to modify factors that directly or indirectly affect these intervals.
References
Zimmerman, D. S., & Tan, H. L. (2021). Epidemiology and risk factors of sudden cardiac arrest. Current opinion in critical care, 27(6), 613–616. https://doi.org/10.1097/MCC.0000000000000896
Gräsner, J. T., Herlitz, J., Tjelmeland, I. B. M., Wnent, J., Masterson, S., Lilja, G., Bein, B., Böttiger, B. W., Rosell-Ortiz, F., Nolan, J. P., Bossaert, L., & Perkins, G. D. (2021). European Resuscitation Council Guidelines 2021: Epidemiology of cardiac arrest in Europe. Resuscitation, 161, 61–79. https://doi.org/10.1016/j.resuscitation.2021.02.007
Nolan, J. P., Berg, R. A., Andersen, L. W., Bhanji, F., Chan, P. S., Donnino, M. W., Lim, S. H., Ma, M. H., Nadkarni, V. M., Starks, M. A., Perkins, G. D., Morley, P. T., & Soar, J. (2019). Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Template for In-Hospital Cardiac Arrest: A Consensus Report From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia). Circulation, 140(18), e746–e757. https://doi.org/10.1161/CIR.0000000000000710
Wnent, J., Masterson, S., Maurer, H., Tjelmeland, I., Herlitz, J., Rosell Ortiz, F., Kurbach, E., Bossaert, L., Perkins, G., & Gräsner, J. T. (2022). European Registry of Cardiac Arrest - Study-THREE (EuReCa THREE) - An international, prospective, multi-centre, three-month survey of epidemiology, treatment and outcome of patients with out-of-hospital cardiac arrest in Europe - The study protocol. Resuscitation plus, 12, 100314. https://doi.org/10.1016/j.resplu.2022.100314
Budimski, M., Jakšić Horvat, K., Momirović Stojković, M., & Fišer, Z. (2017). Eureca Serbia 2015-2016: Two-year analysis. Journal Resuscitatio Balcanica, 3(6), 18-21. https://doi.org/10.5937/JRB1706018B
Ivošević, A., Tomić, B., & Lajko, N. (2018). Sensitivity of OHCA recognition in the emergency dispatch center of Subotica. Journal Resuscitatio Balcanica, 4(9), 85-88. https://doi.org/10.5937/JRB1809085I
Gräsner JT, Lefering R, Koster RW, et al. EuReCa ONE-27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation. 2016;105:188-195. https://doi.org/10.1016/j.resuscitation.2016.06.004
Fišer Z, Vlajović S, Jakšić Horvat K, Raffay V. EURECA Srbija ONE 2014 - vanbolnički srčani zastoj - mesto događaja. Journal Resuscitatio Balcanica. 2015;1(1):9-11.https://doi.org/10.5937/JRB1501009F
Đorđević Vujović N, Lazić A, Ranđelović S. EuReCa_Srbija - šta smo naučili?. Journal Resuscitatio Balcanica. 2019;5(14):206-10. https://doi.org/10.5937/JRB1914206D.
Danielis M, Chittaro M, De Monte A, Trillò G, Durì D. A five-year retrospective study of out-of-hospital cardiac arrest in a north-east Italian urban area. Eur J Cardiovasc Nurs. 2019;18(1):67-74. https://doi.org/10.1177/1474515118786677
Gräsner JT, Wnent J, Herlitz J, et al. Survival after out-of-hospital cardiac arrest in Europe - Results of the EuReCa TWO study. Resuscitation. 2020;148:218-226. https://doi.org/10.1016/j.resuscitation.2019.12.042
Tijanić J, Raffay V, Budimski M. EuReCa 2017 - praćenje srčanog zastoja u R. Srbiji - šestomesečni izveštaj. Journal Resuscitatio Balcanica. 2017;3(7):37-40. https://doi.org/10.5937/JRB1707013T
Fišer, Z., Vlajović, S., Jakšić Horvat, K., & Raffay, V. (2015). EURECA Serbia ONE 2014: Out of hospital cardiac arrest: Venue of accident. Journal Resuscitatio Balcanica, 1(1), 9-11. https://doi.org/10.5937/JRB1501009F
Hawkes C, Booth S, Ji C, et al. Epidemiology and outcomes from out-of-hospital cardiac arrests in England. Resuscitation. 2017;110:133-140. doi:10.1016/j.resuscitation.2016.10.030
Nikolovski SS, Lazic AD, Fiser ZZ, et al. Initial Outcomes and Survival of Out-of-Hospital Cardiac Arrest: EuReCa Serbia Multicenter Cohort Study. Cureus. 2021;13(10):e18555. https://doi.org/10.7759/cureus.18555
Jakšić Horvat K, Budimski M, Momirović Stojković M, Holcer Vukelić S. EURECA one 2014 - analiza povratka spontane cirkulacije (ROSC). Journal Resuscitatio Balcanica. 2015;1(2):9-13. https://doi.org/10.5937/JRB1502009J
Milić S, Raffay V. EuReCa_Serbia - koliko smo napredovali?. Journal Resuscitatio Balcanica. 2018;4(10):103-7. https://doi.org/10.5937/JRB1810108M
Yan S, Gan Y, Jiang N, et al. The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis. Crit Care. 2020;24(1):61. https://doi.org/10.1186/s13054-020-2773-2
Uy-Evanado A, Chugh HS, Sargsyan A, et al. Out-of-Hospital Cardiac Arrest Response and Outcomes During the COVID-19 Pandemic. JACC Clin Electrophysiol. 2021;7(1):6-11. https://doi.org/10.1016/j.jacep.2020.08.010
Majewski D, Ball S, Talikowska M, Belcher J, Brits R, Finn J. Do differences in emergency medical services (EMS) response time to an arrest account for the survival differences between EMS-witnessed and bystander-witnessed out of hospital cardiac arrest?. Resusc Plus. 2024;19:100696. https://doi.org/10.1016/j.resplu.2024.100696
Park HA, Ahn KO, Lee EJ, Park JO, On Behalf Of The Korean Cardiac Arrest Research Consortium KoCARC Investigators. Association between Survival and Time of On-Scene Resuscitation in Refractory Out-of-Hospital Cardiac Arrest: A Cross-Sectional Retrospective Study. Int J Environ Res Public Health. 2021;18(2):496. https://doi.org/10.3390/ijerph18020496
de Graaf C, Donders DNV, Beesems SG, Henriques JPS, Koster RW. Time to Return of Spontaneous Circulation and Survival: When to Transport in out-of-Hospital Cardiac Arrest?. Prehosp Emerg Care. 2021;25(2):171-181. https://doi.org/10.1080/10903127.2020.1752868