UZRASNO I POLNO SPECIFIČNE KARAKTERISTIKE OBOLELIH OD COVID-19 U AUTONOMNOJ POKRAJINI VOJVODINI U 2020. GODINI
Sažetak
Uvod: Kliničke manifestacije koronavirusne bolesti-2019 (engl. Coronavirus disease 2019- COVID-19) variraju od asimptomatskih do teških kliničkih oblika. Činioci koji utiču na nepovoljan tok bolesti, uključujući pol i uzrast obolelih, se još uvek proučavaju.
Cilj rada: Utvrditi polne i uzrasno specifične karakteristike obolelih od COVID-19 u periodu od marta do decembra 2020. godine na teritoriji Autonomne pokrajine Vojvodine.
Materijal i metode: Za obradu podataka korišćen je deskriptivni metod. Podaci o laboratorijskim potvrđenim slučajevima COVID-19 su preuzeti iz baze epidemiološkog nadzora Instituta za javno zdravlje Vojvodine i analizirani retrospektivno. Prema težini bolesti, slučajevi su klasifikovani kao: asimptomatski, blagi, teški ili kritični. Registrovani slučajevi COVID-19 su analizirani po polu i uzrastu u odnosu na težinu kliničke slike, a rezultati su prikazani tabelarno i grafički.
Rezultati: U posmatranom periodu registrovano je ukupno 78106 slučajeva COVID-19 (incidencija 4217/100.000). Posmatrano po polu, 50,8% obolelih su bili ženskog pola. Najviša uzrasno specifična stopa incidencije COVID-19 je registrovana u uzrastu od 30 do 59 godina (5876/100.000). Teška i kritična forma COVID-19 bila je češća u uzrastu ≥ 60 godina života (18,0-39,0%). Asimptomatski tok bolesti je zastupljeniji kod najstarijih ≥80 godina (16,0%) i najmlađih <9 godina života (13,0%). Specifična stopa incidencije COVID-19 bila je 1,6-2,4 puta viša kod muškaraca kada je reč o teškim i kritičnim formama bolesti.
Zaključak: U ranoj fazi pandemije COVID-19, težina kliničke slike je varirala u odnosu na pol i uzrast obolelih. Najviše je bilo pogođeno odraslo radno aktivno stanovništvo ali su teže i životno ugrožavajuće forme bolesti češće registrovane kod najstarijih pacijenata predominantno muškog pola.
Ključne reči: COVID-19; SARS-CoV-2; pol; starost; težina bolesti;
Reference
- Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020;7(1):11.
- Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clin Chim Acta. 2020;508:254-266.
- World Health Organisation [homepage on the Internet]. Coronavirus disease (COVID-19) pandemic. About the virus [updated 2021 April 14; cited 2021 October 31]. Available from: https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/novel-coronavirus-2019-ncov.
- World Health Organisation [homepage on the Internet]. Тhe impact of COVID-19 on global health goals [updated 2021 May 20; cited 2022 January 20]. Available from: https://www.who.int/news-room/spotlight/the-impact-of-covid-19-on-global-health-goals.
- Ristić M, Milosavljević B, Vapa S, Marković M, Petrović V. Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study. PLoS One. 2021;16(7):e0254516.
- Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features. Evaluation, and Treatment of Coronavirus (COVID-19). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Updated 2022 Jan 5; cited 2022 January 22]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK554776/.
- Ristić M, Nikolić N, Čabarkapa V, Turkulov V, Petrović V. Validation of the STANDARD Q COVID-19 antigen test in Vojvodina, Serbia. PLoS One. 2021;16(2):e0247606.
- Haleem A, Javaid M, Vaishya R. Effects of COVID-19 pandemic in daily life. Curr Med Res Pract. 2020;10(2):78-79.
- World Health Organisation [homepage on the Internet]. Impact of COVID-19 on people's livelihoods, their health and our food systems [updated 2020 October 13; cited 2022 January 10]. Available from: https://www.who.int/news/item/13-10-2020-impact-of-covid-19-on-people's-livelihoods-their-health-and-our-food-systems.
- Davies NG, Klepac P, Liu Y, Prem K, Jit M, CMMID COVID-19 working group, et al. Age-dependent effects in the transmission and control of COVID-19 epidemics. Nat Med. 2020;26(8):1205-1211.
- Ancochea J, Izquierdo JL, Soriano JB. Evidence of Gender Differences in the Diagnosis and Management of Coronavirus Disease 2019 Patients: An Analysis of Electronic Health Records Using Natural Language Processing and Machine Learning. J Womens Health (Larchmt). 2021;30(3):393-404.
- Nekaeva ES, Bolshakova AE, Malysheva ES, Galova EA, Makarova EV, Nekrasova TA, et al. Gender Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults. Sovrem Tekhnologii Med. 2021;13(4):16-24.
- Statistical Office of the Republic of Serbia. Population estimates for 2019. Belgrade 2019. [updated 2021 December 23; cited 2022 January 12] Available from: https://publikacije.stat.gov.rs/G2020/Pdf/G20201172.pdf.
- Galanti M, Birger R, Ud-Dean M, Filip I, Morita H, Comito D, et al. Rates of asymptomatic respiratory virus infection across age groups. Epidemiol Infect. 2019;147:e176.
- Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. 2020;395(10229):1054-1062.
- Yoon S, Li H, Lee KH, Hong SH, Kim D, Im H, et al. Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review. Medicina (Kaunas). 2020;56(9):474.
- Wyper GMA, Assunção R, Cuschieri S, Devleesschauwer B, Fletcher E, Haagsma JA, et al. Population vulnerability to COVID-19 in Europe: a burden of disease analysis. Arch Public Health. 2020 Jun 18;78:57. Corrected and republished from: Arch Public Health. 2020;78:47.
- Cinislioglu AE, Cinislioglu N, Demirdogen SO, Sam E, Akkas F, Altay MS et al. The relationship of serum testosterone levels with the clinical course and prognosis of COVID-19 disease in male patients: A prospective study. Andrology. 2022;10(1):24-33.
- Porcheddu R, Serra C, Kelvin D, Kelvin N, Rubino S. Similarity in Case Fatality Rates (CFR) of COVID-19/SARS-COV-2 in Italy and China. J Infect Dev Ctries. 2020;14(2):125-128.
- Wenham C, Smith J, Morgan R; Gender and COVID-19 Working Group. COVID-19: the gendered impacts of the outbreak. Lancet. 2020;395(10227):846-848.
- Rod JE, Oviedo-Trespalacios O, Cortes-Ramirez J. A brief-review of the risk factors for covid-19 severity. Rev Saude Publica. 2020;54:60.
- Bajaj V, Gadi N, Spihlman AP, Wu SC, Choi CH, Moulton VR. Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections? Front Physiol. 2021;11:571416.