POSTKOVID STANJE- PLUĆNO ILI SISTEMSKO, REVERZIBILNO ILI IREVERZIBILNO?

  • vesna_skodric.trifunovic Univerzitet u Beogradu, Medicinski fakultet, Beograd, Srbija; Univerzitetski klinički centar Srbije, Klinika za pulmologiju, Beograd, Srbija
Ključne reči: postkovid, oporavak, plućna funkcija, plućna fibroza

Sažetak


Pacijenti oboleli od kovida otpuštali su se iz kovid bolnica i sa kovid odeljenja bez precizne procene stepena oporavka. Najveći broj pacijenata potpuno se oporavio. Ipak, oko 30% imalo je prolongirane simptome, nezavisne od težine kliničke slike kovida. Nije postojala korelacija između težine bolesti i težine postkovid sindroma. U skladu sa NICE 2020 preporukama termin long covid uključuje simptomatski COVID- 19 ( period 4-12 nedelja nakon akutne bolesti) i postkovid 19 sindrom. Prema Svetskoj zdravstvenoj organizaciji postkovid 19 sindrom je stanje koje se razvija kod osobe koja je imala potvrđenu ili verovatnu kovid infekciju obično tri meseca nakon bolesti COVID -19, sa simptomima koji traju najmanje dva meseca i ne mogu se objasniti drugom dijagnozom.  Prolongirani umor, otežano disanje i neuropsihijatrijske smetnje najčešće su postkovid tegobe. Najčešća respiratorna postkovid manifestacija je uporna dispneja, dok je perzistentna plućna fibroza bila izuzetno retka. Kod više od polovine pacijenata koji su imali tešku kovid pneumoniju nije bilo apsolutne korelacije između nalaza plućne funkcije i nalaza skenera grudnog koša, tj. poremećaj disajne funkcije perzistirao je i nakon potpune radiografske regresije. Dominantna manifestacija ovog poremećaja bila je snižena vrednost parametara difuzijskog kapaciteta pluća ( TLCOc i KCOc), dok su vrednosti spirometrije bile uredne kod većine postkovid pacijenata. Venski tromboembolizam, miokarditis, anksiozno-depresivni poremećaj, zaboravnost i opadanje kose u formi telogenog efluvijuma neke su od ozbiljnih postkovid komplikacija. Značajnom broju pacijenata bila je neophodna fizikalna rehabilitacija.

Reference

1. Laban M. Da li postkovid zaista postoji? U: Stjepanović M, Popević S, Dimić-Janjić Sanja, urednici. Odabrana poglavlja iz pulmologije. Beograd: Medicinski fakultet u Beogradu; 2023.


2. Overview /COVID -19 rapid guideline: managing of  long- term effects of COVID-19/ Guidance NICE. National Institute for Health and Care Excellence. 18 December 2020. Retrieved  18 December 2020..


3. Post COVID Conditions (e.g. LongCOVID). IDSA, last reviewed Oct 6, 2021.


4. Nasserie T, et al. Assessment of the Frequency and variety of persistent symptoms among patients with COVID 19: A systematic review. JAMA Netw Open.2021.


5. Fernandez-de-las Penas C, et al. Long-term post - COVID symptoms and associated risk factors in previously hospitalized patients: A multicenter study. J  Infect 2021 Aug; 83 (2): 237- 279.


6. Liang L, et al. Three- month Follow-up Study of Survivors of Corona Disease 2019 after Discharge. J Korean Med Sci. 2020.


7.  Chaolin Huang, Lixue Huang, Yeming Wang, Xia Li, Lili Ren, Xiaoying Gu, Liang Kang, Li Guo, Min Liu, Xing Zhou, Jianfeng Luo, Zhenghui Huang, Shengjin Tu, Yue Zhao, Li Chen, Decui Xu, Yanping Li, Caihong Li, Lu Peng, Yong Li, Wuxiang Xie, Dan Cui, Lianhan Shang, Guohui Fan, Jiuyang Xu, Geng Wang, Ying Wang, Jingchuan Zhong, Chen Wang  Jianwei Wang, Dingyu Zhang, Bin Cao. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397: 220-32.


8. Maltezou H, Pavli A, Tsakris A, Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021 May 12;9 (5):497.


9. Mazza MG, De Lorenzo R, Conte C, Polleti S, Benedetta V, Bolettini I, Melloni E, Furlan R, Ciceri F, Querini P, Benedetti F. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behal Immun 2020 Oct; 89: 594-600.


10. Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJH. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. The Lancet, Vol 8, Issue 5; P416-427; May 01, 2021.


11. AD Desai,  M Lavelle, BC Boursigout, EY Wan. Long-term complications of COVID-19. J Physiol Cell Physiol. 2022 Jan 1; 322(1): C1-C11.


12. Mandal S, Barnett J, Brill SE, Brown JS, Denneny EK, Hare SS, Heightman M, Hillman TE, Jacob J, Jarvis HC, Lipman MCI, Naidu SB, Nair A, Porter JC, Tomlinson GS, Hurst JR; ARC Study Group. Long -COVID: a cross -sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax 76: 396–398, 2021.


13. Long Term Effects of COVID 19. Centers for Disease Control and Prevention. Retrieved 27 November 2020.


14.  Jovanović D. COVID 19 - odabrani aspekti, Beograd, Prof. dr Dragana Jovanović, 2021.


15. Ramacciotti E, Agati L, Calderaro D, at al. Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised, controlled trial. The Lancet, Vol 399, Issue 10319; Jan01;2021, 50-59


16. E. Ganesanne. Pneumomediastinum in COVID-19 disease: Clinical review with emphasis on emergency management. J Am Coll Emerg Physicians Open. 2023 Apr; 4 (2):e12935.


17. Zhonghua Jie He He Hu Xi Za Zhi. Recommendations for respiratory rehabilitation of COVID -19 in adult. 202; 43(0): E029.


18. Zečević M, Kotur N, Ristivojević B, Gašić V, Škodrić -Trifunović V, Stjepanović M, Stevanović G, Lavadinović L, Zukić B, Pavlović S, Stanković B. Genome-Wide Association Study of COVID-19 Outcomes Reveals Novel Host Genetic Risk Loci in the Serbian Population. Front Genet. 2022 Jul 14;13:911010.

Objavljeno
2023/12/19
Rubrika
Pregledni članak