Identifikacija terapijskih problema tokom uvođenja usluga farmaceuta na Odeljenju gerijatrije Kliničko-bolnickog centra

  • Ivana Baralić
  • Branka Arsenovic Clinical Department of Geriatrics, Zvezdara University Medical Center, Belgrade, Serbia
  • Katarina Stefanovic Clinical Department of Geriatrics, Zvezdara University Medical Center, Belgrade, Serbia
  • Dragana Trifunovic-Balanovic Primary Healthcare Center, Vozdovac, Belgrade, Serbia
Ključne reči: klinička farmacija, terapijski problem, gerijatrija

Sažetak


Uvod: Višestruki komorbiditeti i polifarmacija dovode gerijatrijske pacijente u povećan rizik od terapijskih proble­ma, što može dovesti do povećanog morbiditeta, mortaliteta i troškova zdravstvene zaštite ovih pacijenata.

Cilj rada: Cilj studije je da identifikuje učestalost i uzroke terapijskih problema kod starijih pacijenata i faktore koji na njih utiču, kao i da proceni implementaciju usluga farmaceuta na gerijatrijskom odeljenju.

Metod: Farmaceut je analizirao terapiju hospitalizova­nih pacijenata na odeljenju za gerijatriju, identifikovao tera­pijske probleme i formulisao preporuke za promenu terapije. Terapijski problemi su kategorizovani prema PCNE-DRP klasifikaciji, verzija 9. U studiju je uključeno ukupno 100 pacijenata, od kojih su 52% bili muškarci, prosečne starosti 79,7±7,88 godina.

Rezultati: Prosečan broj identifikovanih terapijskih problema je bio 2,36 po pacijentu. Najčešće uočen problem je bezbednost terapije (44,9%), zatim efikasnost terapije (33,1%) i nepotreban lek u terapiji (22%). Za većinu tera­pijskih problema uzrok je bio neadekvatan izbor leka (61%) i neadekvatan izbor doze (38,1%). Pacijenti sa atrijalnom fi­brilacijom i hroničnom bubrežnom insuficijencijom imali su značajno veći broj terapijskih problema u poređenju sa paci­jentima bez ovih komorbiditeta. Analizirana terapija za 100 hospitalizovanih gerijatrijskih pacijenata zahtevala je ukupno 229 intervencija. Međutim, stopa prihvatanja preporučenih intervencija bila je niska (25,9%).

Zaključak: Prevalencija terapijskih problema kod ge­rijatrijskih pacijenata je visoka, dok je stepen prihvatanja preporuka farmaceuta za promenu terapije nizak. Da bi se unapredila implementacija farmaceutskih usluga i poboljšala zdravstvena zaštita starijih pacijenata, veoma je važno una­prediti saradnju između lekara i farmaceuta. Razumevanje veština farmaceuta može omogućiti prihvatanje farmaceuta kao dela multidisciplinarnog tima i uspešnu implementaciju farmaceutskih usluga.

Reference

Gammie T, Vogler S, Babar ZUD. Economic Evaluation of Hospital and Community Pharmacy Services. Ann Pharmacother. 2017;51(1):54-65. doi:10.1177/1060028016667741

Hanlon JT, Artz MB. Drug-related problems and pharmaceutical care: what are they, do they matter, and what’s next? Med Care. 2001;39(2):109-112. doi:10.1097/00005650-200102000-00001

Johnson JA, Bootman JL. Drug-related morbidity and mortality. A cost-of-illness model. Arch Intern Med. 1995;155(18):1949-1956.

Pharmaceutical Care Network Europe (PCNE). The PCNE classification V9.00. https://www.pcne.org/upload/files/334_PCNE_classification_V9-0.pdf (2019). Accessed 16 Aug 2023.

Qu C, Meng L, Wang N, et al. Identify and categorize drug-related problems in hospitalized surgical patients in China. Int J Clin Pharm. 2019;41(1):13-17. doi:10.1007/s11096-018-0777-7

Selcuk A, Sancar M, Okuyan B, Demirtunc R, Izzettin FV. The potential role of clinical pharmacists in elderly patients during hospital admission. Pharmazie. 2015;70(8):559-562.

Somers A, Robays H, De Paepe P, Van Maele G, Perehudoff K, Petrovic M. Evaluation of clinical pharmacist recommendations in the geriatric ward of a Belgian university hospital. Clin Interv Aging. 2013;8:703-709. doi:10.2147/CIA.S42162

Van der Linden L, Hias J, Dreessen L, et al. Medication review versus usual care to improve drug therapies in older inpatients not admitted to geriatric wards: a quasi-experimental study (RASP-IGCT). BMC Geriatr. 2018;18(1):155. doi:10.1186/s12877-018-0843-y

Christensen M, Lundh A. Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database Syst Rev. 2016;2(2):CD008986. doi:10.1002/14651858.CD008986.pub3

Ertuna E, Arun MZ, Ay S, Koçak FÖK, Gökdemir B, İspirli G. Evaluation of pharmacist interventions and commonly used medications in the geriatric ward of a teaching hospital in Turkey: a retrospective study. Clin Interv Aging. 2019;14:587-600. doi:10.2147/CIA.S201039

Jourdan JP, Muzard A, Goyer I, et al. Impact of pharmacist interventions on clinical outcome and cost avoidance in a university teaching hospital. Int J Clin Pharm. 2018;40(6):1474-1481. doi:10.1007/s11096-018-0733-6

Renaudin P, Boyer L, Esteve MA, Bertault-Peres P, Auquier P, Honore S. Do pharmacist-led medication reviews in hospitals help reduce hospital readmissions? A systematic review and meta-analysis. Br J Clin Pharmacol. 2016;82(6):1660-1673. doi:10.1111/bcp.13085

Gazibara T, Nurkovic S, Kisic-Tepavcevic D, et al. Pharmacotherapy and over-the-counter drug use among elderly in Belgrade, Serbia. Geriatric Nursing. 2013;34(6):486-490. doi:10.1016/j.gerinurse.2013.08.002

Kovačević SV, Miljković B, Vučićević K, et al. Elderly polypharmacy patients’ needs and concerns regarding medication assessed using the structured patient-pharmacist consultation model. Patient Educ Couns. 2017;100(9):1714-1719. doi:10.1016/j.pec.2017.05.001

Jacobi J. CLINICAL PHARMACISTS: PRACTITIONERS WHO ARE ESSENTIAL MEMBERS OF YOUR CLINICAL CARE TEAM. Revista Médica Clínica Las Condes. 2016;27(5):571-577. doi:10.1016/j.rmclc.2016.09.002

O’Mahony D, O’Sullivan D, Byrne S, O’Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213-218. doi:10.1093/ageing/afu145

Gillespie U, Alassaad A, Henrohn D, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169(9):894-900. doi:10.1001/archinternmed.2009.71

Halvorsen KH, Ruths S, Granas AG, Viktil KK. Multidisciplinary intervention to identify and resolve drug-related problems in Norwegian nursing homes. Scand J Prim Health Care. 2010;28(2):82-88. doi:10.3109/02813431003765455

Spinewine A, Dhillon S, Mallet L, Tulkens PM, Wilmotte L, Swine C. Implementation of ward-based clinical pharmacy services in Belgium--description of the impact on a geriatric unit. Ann Pharmacother. 2006;40(4):720-728. doi:10.1345/aph.1G515

Raimbault-Chupin M, Spiesser-Robelet L, Guir V, et al. Drug related problems and pharmacist interventions in a geriatric unit employing electronic prescribing. Int J Clin Pharm. 2013;35(5):847-853. doi:10.1007/s11096-013-9821-9

Hailu BY, Berhe DF, Gudina EK, Gidey K, Getachew M. Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions. BMC Geriatr. 2020;20(1):13. doi:10.1186/s12877-020-1413-7

Abunahlah N, Elawaisi A, Velibeyoglu FM, Sancar M. Drug related problems identified by clinical pharmacist at the Internal Medicine Ward in Turkey. Int J Clin Pharm. 2018;40(2):360-367. doi:10.1007/s11096-017-0585-5

Al-Baghdadi H, Koca Al-Baghdadi Ç, Abdi A, et al. Introducing clinical pharmacy services to cardiovascular clinics at a university hospital in Northern Cyprus. Int J Clin Pharm. 2017;39(6):1185-1193. doi:10.1007/s11096-017-0534-3

Zaman Huri H, Fun Wee H. Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC Endocr Disord. 2013;13:2. doi:10.1186/1472-6823-13-2

Kovačević M, Vezmar Kovačević S, Miljković B, Radovanović S, Stevanović P. The prevalence and preventability of potentially relevant drug-drug interactions in patients admitted for cardiovascular diseases: A cross-sectional study. Int J Clin Pract. 2017;71(10). doi:10.1111/ijcp.13005

Leendertse AJ, Egberts ACG, Stoker LJ, van den Bemt PMLA, HARM Study Group. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890-1896. doi:10.1001/archinternmed.2008.3

Papaioannou A, Clarke JA, Campbell G, Bédard M. Assessment of adherence to renal dosing guidelines in long-term care facilities. J Am Geriatr Soc. 2000;48(11):1470-1473. doi:10.1111/j.1532-5415.2000.tb02639.x

Hanlon JT, Lindblad CI, Gray SL. Can clinical pharmacy services have a positive impact on drug-related problems and health outcomes in community-based older adults? Am J Geriatr Pharmacother. 2004;2(1):3-13. doi:10.1016/s1543-5946(04)90002-5

Spinewine A, Swine C, Dhillon S, et al. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc. 2007;55(5):658-665. doi:10.1111/j.1532-5415.2007.01132.x

Thillainadesan J, Gnjidic D, Green S, Hilmer SN. Impact of Deprescribing Interventions in Older Hospitalised Patients on Prescribing and Clinical Outcomes: A Systematic Review of Randomised Trials. Drugs Aging. 2018;35(4):303-319. doi:10.1007/s40266-018-0536-4

Lisby M, Thomsen A, Nielsen LP, et al. The effect of systematic medication review in elderly patients admitted to an acute ward of internal medicine. Basic Clin Pharmacol Toxicol. 2010;106(5):422-427. doi:10.1111/j.1742-7843.2009.00511.x

Peled O, Vitzrabin Y, Beit Ner E, et al. Acceptance rate of clinical pharmacists’ recommendations—an ongoing journey for integration. Front Pharmacol. 2023;14:1253990. doi:10.3389/fphar.2023.1253990

Objavljeno
2024/04/23
Kako citirati
Baralić, I., Arsenovic, B., Stefanovic, K., & Trifunovic-Balanovic, D. (2024). Identifikacija terapijskih problema tokom uvođenja usluga farmaceuta na Odeljenju gerijatrije Kliničko-bolnickog centra. Opšta Medicina, 30(1-2), 15-28. https://doi.org/10.5937/opmed0-48159
Rubrika
originalni rad