Redox-metabolic signature of breast cancer

Andjelika Kalezić; Biljana Srdić Galić; Aleksandra Korać; Aleksandra Janković; Bato Korać

Andjelika Kalezić University of Belgrade – Institute for Biological Research "Siniša Stanković"
Biljana Srdić Galić University of Novi Sad – Faculty of Medicine
Aleksandra Korać University of Belgrade – Faculty of Biology
Aleksandra Janković University of Belgrade – Institute for Biological Research "Siniša Stanković"
Bato Korać University of Belgrade – Institute for Biological Research "Siniša Stanković"; University of Belgrade – Faculty of Biology

Abstract

Redox and metabolic homeostasis are essential for maintaining the body's energy needs. They represent an integrative, evolutionarily conserved response, whose molecular mechanisms have been constantly evolving and adapting to the altered microenvironment, especially in aerobic organisms. This refers to the maintenance of homeostasis in both physiological and pathological conditions, from metabolic disorders, diabetes, obesity, cardiovascular and neurodegenerative diseases, to cancer. Precisely in cancer, redox-metabolic reprogramming is a key hallmark of neoplastic transformation that allows it to create an adaptive environment. This is strongly coupled to the interaction of cancer cells with their microenvironment. In breast cancer, the principal component of the tumor milieu is adipose tissue. Adipocytes and cancer cells are in cooperation rather than in competition. Establishing or disrupting their relationship is crucial for the initiation and progression of breast cancer, as well as for metastatic potential and therapeutic resistance. However, several issues regarding the production of reactive oxygen species, the organization of antioxidant defense, and metabolic reprogramming in breast cancer are unresolved. This is especially true of the role of redox-metabolic transcription factors involved in cancer and adipose tissue reprogramming, primarily Nrf2 (nuclear factor erythroid 2-related factor 2). This is an attempt to review and provide an overview of the current state and perspectives in discovering the mechanisms of redox-metabolic reprogramming in breast cancer.