Endocrine disrupting mechanisms and effects of pesticides
Abstract
Pesticides are important agents that are intentionally introduced into the environment to control various pests and disease carriers, often by killing them. Although pesticides have many important objectives, including protection against crop loss and vector-borne diseases, there are significant concerns over the potential toxicity of pesticides on various organisms, including humans. The frequent use of pesticides in agriculture has led to the long-term exposure of humans to different pesticide residues. Exposure to pesticides has been linked to disturbances in the endocrine system of animals and humans. There are increasing data on the relation between lipophilic pesticides with low biodegradability and changes in reproductive functions and parameters of male and female animals. But more epidemiological and detailed information is necessary on the probability and strength of pesticide exposure-outcome relations regarding endocrine-disrupting effects.
References
Pesticides [Internet]. European Food Safety Autority (EFSA) [cited 2021 Dec 15]. Available from: https://www.efsa.europa.eu/en/topics/topic/pesticides>
Krieger R. Hayes' Handbook of Pesticide Toxicology: Principles and agents. San Diego, CA: Academic Press; 2001. 2342p.
Aktar MW, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: their benefits and hazards. Interdiscip Toxicol. 2009;2(1):1-12.
Pesticide Toxicity and Hazard [Internet]. British Columbia Ministiry of Agriculture [cited 2021 Dec 15]. Available from: https://www2.gov.bc.ca/assets/gov/farming-natural-resources-and-industry/agriculture-and-seafood/animal-and-crops/plant-health/pesticide-toxicity-hazard.pdf>
Costa LG. Toxic effects of pesticides. In: Curtis D. Klaassen, editor. Casarett and Doull’s toxicology: The Basic Science of Poisons 9th New York: Mcgraw-Hill; 2008; p.883-930.
Kolpin DW, Thurman EM, Linhart SM. Finding minimal herbicide concentrations in ground water? Try looking for their degradates. Sci Total Environ. 2000;248(2-3):115-22.
Endocrine Disrupting Chemicals [Internet]. World Health Organisation (WHO) [cited 2021 Dec 15]. 2021. Available from: https://apps.who.int/iris/bitstream/handle/10665/78102/WHO_HSE_PHE_IHE_2013.1_eng.pdf>
McKinlay R, Plant J, Bell J, Voulvoulis N. Endocrine disrupting pesticides: implications for risk assessment. Environ Int. 2008;34(2):168-83.
Zala SM, Penn DJ. Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges. Anim Behav. 2004;68(4):649-64.
Garry VF. Pesticides and children. Toxicol Appl Pharmacol. 2004;198(2):152-63.
Mathur V, Bhatnagar P, Sharma RG, Acharya V, Sexana R. Breast cancer incidence and exposure to pesticides among women originating from Jaipur. Environ Int. 2002;28(5):331-6.
Baskin LS, Himes K, Colborn T. Hypospadias and endocrine disruption: is there a connection? Environ Health Perspect. 2001;109(11):1175-83.
Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993;101(5):378-84.
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Jr, Lee DH, et al. Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reprod Toxicol. 2013;38:1-15.
Singer PL. Occupational oligiospermia. J Am Med Dir Assoc. 1949;140:1249.
List of lists: a catalogue of lists of pesticides identifying those associated with particularly harmful health or environmental impacts 2009 edition [Internet]. Pesticide Action Network (PAN). [cited 2021 Dec 15]. Available from: https://www.pan-europe.info/old/Campaigns/pesticides/documents/cut_off/list%20of%20lists.pdf >
Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress: a review. Med Sci Monit. 2004;10(6):141-7.
Giray B, Gürbay A, Hincal F. Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol. Toxicol Lett. 2001;118(3):139-46.
Gultekin F, Ozturk M, Akdogan M. The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch Toxicol. 2000;74(9):533-8.
Ranjbar A, Pasalar P, Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Hum Exp Toxicol. 2002;21(4):179-82.
García J, Ventura MI, Requena M, Hernández AF, Parrón T, Alarcón R. Association of reproductive disorders and male congenital anomalies with environmental exposure to endocrine active pesticides. Reprod Toxicol. 2017;71:95-100.
Mnif W, Hassine AIH, Bouaziz A, Bartegi A, Thomas O, Roig B. Effect of endocrine disruptor pesticides: a review. Int J Environ. 2011;8(6):2265-303.
Roeleveld N, Bretveld R. The impact of pesticides on male fertility. Curr Opin Obstet. 2008;20(3):229-33.
Rattan S, Zhou C, Chiang C, Mahalingam S, Brehm E, Flaws JA. Exposure to endocrine disruptors during adulthood: consequences for female fertility. J Endocrinol. 2017;233(3):R109-R29.
O'Donnell L, Stanton P, de Kretser DM. Endocrinology of the male reproductive system and spermatogenesis. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM et al., editors. Endotext. South Dartmouth (MA): Endotext; 2013; p. 1–57.
Panuwet P, Ladva C, Barr DB, Prapamontol T, Meeker JD, D'Souza PE, et al. Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers. Arch Environ Occup Health. 2018;73(4):205-18.
Goncharov A, Rej R, Negoita S, Schymura M, Santiago-Rivera A, Morse G, et al. Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. Environ Health Perspect. 2009;117(9):1454-60.
Jayaraj R, Megha P, Sreedev P. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment. Interdiscip Toxicol. 2016;9(3-4):90-100.
Beard J, Collaboration ARHR. DDT and human health. Sci Total Environ. 2006;355(1-3):78-89.
Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R. Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006;79(12):1160-9.
Mussi P, Ciana P, Raviscioni M, Villa R, Regondi S, Agradi E, et al. Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT. Brain Res Bull. 2005;65(3):241-7.
Lee HR, Jeung EB, Cho MH, Kim TH, Leung PCK, Choi KC. Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors. J Cell Mol Med. 2013;17(1):1-11.
Zama AM, Uzumcu M. Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes. Endocrinology. 2009;150(10):4681-91.
Harvey CN, Esmail M, Wang Q, Brooks AI, Zachow R, Uzumcu M. Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro. Toxicol Sci. 2009;110(1):95-106.
Gordon JD, Chu AC, Clark G, Chu M, Denison M. Detection of estrogen receptor endocrine disruptor potency of commonly used organochlorine pesticides using the LUMI-CELL ER bioassay. Organohalogen Compd. 2004;66:2967-73.
Pathak R, Mustafa M, Ahmed RS, Tripathi A, Guleria K, Banerjee B. Association between recurrent miscarriages and organochlorine pesticide levels. Clin Biochem. 2010;43(1-2):131-5.
Tyagi V, Garg N, Mustafa M, Banerjee B, Guleria K. Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population. Environ Monit Assess. 2015;187(7):1-9.
Singh P, Volger B, Gordon E. Endosulfan. In: Wexler P, editor. Encyclopedia of Toxicology (Third Edition). Oxford: Academic Press; 2014. p. 341-3.
Amizadeh M, Saryazdi GA. Effects of endosulfan on human health. WebmedCentral TOXICOLOGY 2011;2(12):WMC002617.
Ozmen O, Sahinduran S, Mor F. Pathological and immunohistochemical examinations of the pancreas in subacute endosulfan toxicity in rabbits. Pancreas. 2010;39(3):367-70.
Singh ND, Sharma AK, Dwivedi P, Patil RD, Kumar M. Experimentally induced citrinin and endosulfan toxicity in pregnant Wistar rats: histopathological alterations in liver and kidneys of fetuses. J Appl Toxicol. 2008;28(7):901-7.
Palma P, Palma V, Matos C, Fernandes R, Bohn A, Soares A, et al. Effects of atrazine and endosulfan sulphate on the ecdysteroid system of Daphnia magna. Chemosphere. 2009;74(5):676-81.
Palma P, Palma V, Matos C, Fernandes R, Bohn A, Soares A, et al. Assessment of the pesticides atrazine, endosulfan sulphate and chlorpyrifos for juvenoid-related endocrine activity using Daphnia magna. Chemosphere. 2009;76(3):335-40.
Wilson VS, Lambright CR, Furr JR, Howdeshell KL, Gray Jr LE. The herbicide linuron reduces testosterone production from the fetal rat testis during both in utero and in vitro exposures. Toxicol Lett. 2009;186(2):73-7.
Quignot N, Arnaud M, Robidel F, Lecomte A, Tournier M, Cren-Olivé C, et al. Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats. Reprod Toxicol. 2012;33(3):339-52.
Komsky-Elbaz A, Roth Z. Effect of the herbicide atrazine and its metabolite DACT on bovine sperm quality. Reprod Toxicol. 2017;67:15-25.
Kniewald J, Jakominić M, Tomljenović A, Simić B, Romać P, Vranesić D, et al. Disorders of male rat reproductive tract under the influence of atrazine. J Appl Toxicol. 2000;20(1):61-8.
Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG. Neurotoxicity of pesticides. Acta Neuropathol. 2019;138(3):343-62
Corcellas C, Eljarrat E, Barcelo D. First report of pyrethroid bioaccumulation in wild river fish: A case study in Iberian river basins (Spain). Environ Int. 2015;75:110-16.
Brander SM, Gabler MK, Fowler NL, Connon RE, Schlenk D. Pyrethroid Pesticides as Endocrine Disruptors: Molecular Mechanisms in Vertebrates with a Focus on Fishes. Environ Sci Technol. 2016;50(17):8977-92.
Bhunya SP, Pati PC. Effect of deltamethrin, a synthetic pyrethroid, on the induction of chromosome aberrations, micronuclei and sperm abnormalities in mice. Mutagenesis. 1990;5(3):229-32.
Ben Slima A, Chtourou Y, Barkallah M, Fetoui H, Boudawara T, Gdoura R. Endocrine disrupting potential and reproductive dysfunction in male mice exposed to deltamethrin. Hum Exp Toxicol. 2017;36(3):218-26.
Yang KJ, Lee J, Park HL. Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies. Int J Environ Res Public Health. 2020;17(14):5030.
Bassil KL, Vakil C, Sanborn M, Cole DC, Kaur JS, Kerr KJ. Cancer health effects of pesticides: systematic review. Can Fam Physician. 2007;53(10):1704-11.
Alavanja MC, Ross MK, Bonner MR. Increased cancer burden among pesticide applicators and others due to pesticide exposure. CA: Cancer J. Clin. 2013;63(2):120-42.
Parrón T, Requena M, Hernández AF, Alarcón R. Environmental exposure to pesticides and cancer risk in multiple human organ systems. Toxicol Lett. 2014;230(2):157-65.
Falck Jr F, Ricci Jr A, Wolff MS, Godbold J, Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health. 1992;47(2):143-6.
Alavanja MC, Samanic C, Dosemeci M, Lubin J, Tarone R, Lynch CF, et al. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol. 2003;157(9):800-14.
Prins GS. Endocrine disruptors and prostate cancer risk. Endocr Relat Cancer. 2008;15(3):649.
Settimi L, Masina A, Andrion A, Axelson O. Prostate cancer and exposure to pesticides in agricultural settings. Int J Cancer. 2003;104(4):458-61.
Alavanja MC, Sandler DP, Lynch CF, Knott C, Lubin JH, Tarone R, et al. Cancer incidence in the agricultural health study. Scand J Work Environ Health. 2005;31 suppl 1:39-45.
Dich J, Wiklund K. Prostate cancer in pesticide applicators in Swedish agriculture. The Prostate. 1998;34(2):100-12.
Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Harnly ME. Childhood cancer and agricultural pesticide use: an ecologic study in California. Environ Health Perspect. 2002;110(3):319-24.
Weidner IS, Møller H, Jensen TK, Skakkebæk NE. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ Health Perspect. 1998;106(12):793-6.
Birnbaum LS, Fenton SE. Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect. 2003;111(4):389-94.
Goldman L, Falk H, Landrigan PJ, Balk SJ, Reigart JR, Etzel RA. Environmental pediatrics and its impact on government health policy. Pediatrics. 2004;113(Supplement 3):1146-57.
Waliszewski SM, Aguirre AA, Infanzón RM, Siliceo J. Carry-over of persistent organochlorine pesticides through placenta to fetus. Salud Publica Mex. 2000;42:384-90.
Hardell L, van Bavel B, Lindström G, Eriksson M, Carlberg M. In utero exposure to persistent organic pollutants in relation to testicular cancer risk. Int J Androl. 2006;29(1):228-34.
Eskenazi B, Marks AR, Bradman A, Fenster L, Johnson C, Barr DB, et al. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics. 2006;118(1):233-41.
Binukumar B, Gill KD. Chronic exposure to pesticides-neurological, neurobehavioral and molecular targets of neurotoxicity. In: Stoytcheva, M . (ed.) Pesticides in the modern world-Effects of pesticides exposure. Rijeka, Croatia: InTech; 2013; p. 1–20.
