Endocrine disrupting mechanisms and effects of pesticides

Hatice Gül Anlar; Merve Bacanlı; Nursen Basaran

doi:10.5937/arhfarm71-34291

Hatice Gül Anlar Zonguldak Bülent Ecevit University Faculty of Pharmacy, Department of Pharmaceutical Toxicology
Merve Bacanlı University of Health Sciences Turkey Gülhane Faculty of Pharmacy, Department of Pharmaceutical Toxicology
Nursen Basaran Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Toxicology

DOI: https://doi.org/10.5937/arhfarm71-34291

Ključne reči: Pesticidi, endokrini sistem, reproduktivni sistem, endokrini ometači

Sažetak

Pesticidi su značajna sredstva koja se namerno unose u životnu sredinu kako bi se kontrolisale različite štetočine i prenosioci bolesti, često tako što se ubijaju. Iako postoji mnogo značajnih ciljeva upotrebe pesticida, uključujući zaštitu od gubitka useva i bolesti koje se prenose vektorima, prisutna je značajna zabrinutost zbog potencijalne toksičnosti pesticida po različite organizme, između ostalih i ljude. Česta upotreba pesticida u poljoprivredi dovela je do dugoročne izloženosti ljudi različitim ostacima pesticida. Izlaganje pesticidima povezuje se sa poremećajima endokrinog sistema kod životinja i ljudi. Sve je više podataka koji svedoče o vezi između lipofilnih pesticida sa niskom biorazgradivošću i promena u reproduktivnim funkcijama i parametrima životinja muškog i ženskog pola. Ipak, potrebno je više epidemioloških i detaljnih informacija o verovatnoći i intenzitetu povezanosti između izlaganja pesticidima i ishoda koji se odnose na ometanje rada endokrinog sistema.

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Mehanizmi i posledice delovanja pesticida kao endokrinih ometača

Sažetak

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