Pregled mogućnosti primene natkritičnog ugljenik(IV)-oksida u proizvodnji lekova

  • Stoja Milovanović University of Belgrade – Faculty of Technology and Metallurgy
  • Ivana Lukić Univerzitet u Beogradu – Tehnološko-metalurški fakultet
DOI: https://doi.org/10.5937/arhfarm72-39999
Ključne reči: natkritični CO2, čvrsta disperzija, natkritična impregnacija, generisanje čestica

Sažetak


Primena natkritičnog ugljenik(IV)-oksida (nkCO2) u farmaceutskoj industriji je još uvek nerazvijena, bez obzira na značajan istraživački interes za ovaj procesni medijum pokazan u poslednjim decenijama. NkCO2 tehnologije mogu poboljšati rastvorljivost lekovite supstance, njenu bioraspoloživost i terapijski učinak. Ove tehnologije mogu dovesti do razvoja novih formulacija koje će doprineti smanjenju doze leka, učestalosti uzimanja leka i poboljšati dobrobit pacijenata. S obzirom na značajno smanjenje cene opreme za rad pod visokim pritiscima i sve veću potrebu društva za čistijom proizvodnjom i sigurnijim proizvodima, očekuje se da će uskoro doći do simbioze između natkritičnih i farmaceutskih tehnologija. Stoga je ovaj pregledni rad bio fokusiran na najnovije doprinose nkCO2 tehnologija farmaceutskoj oblasti. Glavni cilj bio je približiti ove tehnologije farmaceutskim stručnjacima. U tu svrhu objašnjene su i diskutovane najčešće korišćene tehnologije: priprema čvrstih disperzija, impregnacija polimera lekovitim supstancama i proizvodnja mikro/nanočestica lekovitih supstanci upotrebom nkCO2.

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Objavljeno
2022/12/29
Broj časopisa
Vol. 72 Br. Notebook 6 (2022): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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