Potencijal upotrebe prirodnih proizvoda za 3D štampu farmaceutskih oblika doziranja primenom fused deposition modeling tehnologije

  • Jelena Čanji Panić Univerzitet u Novom Sadu – Medicinski fakultet, Katedra za farmaciju
  • Nemanja Todorović Univerzitet u Novom Sadu – Medicinski Fakultet, Katedra za farmaciju
  • Ana Stjepanović Univerzitet u Novom Sadu – Medicinski Fakultet, Katedra za farmaciju
  • Mladena Lalić-Popović Univerzitet u Novom Sadu – Medicinski fakultet, Katedra za farmaciju; Centar za medicinska i farmaceutska istraživanja i kontrolu kvalitetat
DOI: https://doi.org/10.5937/arhfarm72-40155
Ključne reči: biopolimeri, prirodna sredstva za dopunjavanje, prirodni plastifikatori, FDM, trodimenzionalno štampanje

Sažetak


Poslednjih godina interesovanje za 3D štampanje lekova je u porastu usled mnogih prednosti ove tehnologije, kao što su visoka fleksibilnost u pogledu doze i farmaceutskog oblika štampanog farmaceutskog proizvoda. Fused deposition modeling (FDM) je jedna od najpopularnijih tehnologija 3D štampanja u farmaciji, zbog svoje niske cene i jednostavnosti. Predmet ovog preglednog rada je upotreba prirodnih proizvoda kao biorazgradivih i biokompatibilnih materijala sa dobrim bezbednosnim profilima u FDM 3D štampanju farmaceutskih proizvoda. Prirodni proizvodi kao što su alginat, hitozan i skrob već su primenjivani kao ekscipijenti u FDM 3D štampanim farmaceutskim oblicima lekova, dok drugi, poput šelaka i zeina, pokazuju potencijal, ali još uvek nisu korišćeni za 3D štampu farmaceutskih oblika lekova. Uloge ovih ekscipijenasa u formulaciji filamenata za FDM 3D štampu mogu biti različite, npr. punioci, nosači matriksa ili modifikatori oslobađanja. Takođe je razmatrana mogućnost inkorporacije aktivnih farmaceutskih sastojaka prirodnog porekla u filamente. Visoke temperature štampanja ograničavaju upotrebu prirodnih proizvoda u FDM 3D štampanju. Međutim, adekvatan izbor termoplastičnog materijala i parametara štampanja može proširiti upotrebu prirodnih proizvoda u FDM 3D štampanju farmaceutskih proizvoda.

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Objavljeno
2022/12/29
Broj časopisa
Vol. 72 Br. Notebook 6 (2022): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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