PERINATAL COMPLICATIONS, ENVIRONMENTAL FACTORS AND AUTISM SPECTRUM DISORDERS

Vanja Mandic Maravic; Milica Pejovic Milovancevic; Tatjana Pekmezovic; Marija Pljesa Ercegovac; Marija Mitkovic Voncina; Dusica Lecic Tosevski

doi:10.5937/mp67-12844

Vanja Mandic Maravic Institute of mental health, Belgrade, Serbia
Milica Pejovic Milovancevic School of medicine, University of Belgrade Institute of mental health, Belgrade
Tatjana Pekmezovic Institute of epidemiology, School of medicine, University of Belgrade
Marija Pljesa Ercegovac Institute for medical and clinical biochemistry, School of medicine, University of Belgrade
Marija Mitkovic Voncina School of medicine, University of Belgrade Institute of mental health, Belgrade
Dusica Lecic Tosevski School of medicine, University of Belgrade Institute of mental health Serbian Academy of Sciences and Arts

DOI: https://doi.org/10.5937/mp67-12844

Sažetak

Objectives: Autism spectrum disorders (ASD) are caracterized by qualitative impairment of social interactions, impairment of verbal and nonverbal communication, as well as restricted interests and repetitive behavior. ASD represent a group of complex psychiatric disorders, with both genetic and environmental factors implicated in their etiology. Recent neuroanatomical and epidemiological studies point out to prenatal and early postnatal genesis of ASD.

Aim: In this review, we present recent studies that explored the effect of environmental, prenatal and perinatal risk factors on development of ASD. Also, we point out to those factors that have been proven to have the strongest association with ASD, and emphasize a very complex interaction of individual factors that might eventually lead to manifestation of this group of disorders.

Conslusion: A precise defining of risk factors might provide more insight not only into etiology of ASD, but also might give us a possibility for early recognition and possible prevention of autism spectrum disorders, especially in susceptible individuals. It is also a first step in defining the basis of the gene-environment interaction mechanism, which might enable the development of an individualised therapeutic approach for this group of disorders.

Key words: autism spectrum disorders, autism, risk factor, perinatal complications.

Biografije autora

Vanja Mandic Maravic, Institute of mental health, Belgrade, Serbia

MD, Department for psychotic disorders

Milica Pejovic Milovancevic, School of medicine, University of Belgrade Institute of mental health, Belgrade

Departmenf of psychiatry, associate professor

Tatjana Pekmezovic, Institute of epidemiology, School of medicine, University of Belgrade

Department of epidemiology, professor

Marija Pljesa Ercegovac, Institute for medical and clinical biochemistry, School of medicine, University of Belgrade

Department of Medical and clinical biochemistry, professor

Marija Mitkovic Voncina, School of medicine, University of Belgrade Institute of mental health, Belgrade

Department of psychiatry, assistant professor

Dusica Lecic Tosevski, School of medicine, University of Belgrade Institute of mental health Serbian Academy of Sciences and Arts

Department for psychiatry, professor

Institute of mental health, director

Serbian Academy of Sciences and Arts, member

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