PERINATAL COMPLICATIONS, ENVIRONMENTAL FACTORS AND AUTISM SPECTRUM DISORDERS
Abstract
Objectives: Autism spectrum disorders (ASD) are caracterized by qualitative impairment of social interactions, impairment of verbal and nonverbal communication, as well as restricted interests and repetitive behavior. ASD represent a group of complex psychiatric disorders, with both genetic and environmental factors implicated in their etiology. Recent neuroanatomical and epidemiological studies point out to prenatal and early postnatal genesis of ASD.
Aim: In this review, we present recent studies that explored the effect of environmental, prenatal and perinatal risk factors on development of ASD. Also, we point out to those factors that have been proven to have the strongest association with ASD, and emphasize a very complex interaction of individual factors that might eventually lead to manifestation of this group of disorders.
Conslusion: A precise defining of risk factors might provide more insight not only into etiology of ASD, but also might give us a possibility for early recognition and possible prevention of autism spectrum disorders, especially in susceptible individuals. It is also a first step in defining the basis of the gene-environment interaction mechanism, which might enable the development of an individualised therapeutic approach for this group of disorders.
Key words: autism spectrum disorders, autism, risk factor, perinatal complications.
References
Van Engeland H, Buitelaar JK. Autism spectrum disorders. In: Rutter M, Bishop JVM, Pine DS, Scott S, Stevenson J, Taylor E, Thapar A, editors. Rutter’s Child and Adolescent Psychiatry 5th edition. Blackwell Publishing Limited; 2008. p. 759-782.
World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). Geneva: WHO; 1992.
Hus V, Pickles A, Cook EH Jr, Risi S, Lord C. Using the autism diagnostic interview--revised to increase phenotypic homogeneity in genetic studies of autism. Biol Psychiatry. 2007; 61(4):438-448.
Christensen DL, Baio J, Van Naarden Braun K, Bilder D, Charles J, Constantino JN, et al..., Centers for Disease Control and Prevention (CDC). Prevalence and characteristics of autism spectrum disorder among children aged 8 years--autism and developmental disabilities monitoring network, 11 Sites, United States, 2012. MMWR Surveill Summ. 2016; 65(3):1-23.
Baron-Cohen S, Knickmeyer RC, Belmonte MK. Sex differences in the brain: implications for explaining autism. Science. 2005; 310:819–823.
Mandic-Maravic V, Pejovic-Milovancevic M, Mitkovic-Voncina M, Kostic M, Aleksic-Hil O, Radosavljev-Kircanski J, Mincic T, Lecic-Tosevski D. Sex differences in autism spectrum disorders: does sex moderate the pathway from clinical symptoms to adaptive behavior? Sci Rep. 2015; 5:10418.
Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders: Autism and Developmental Disabilities Monitoring Network. MMWR. 2009; 58(SS-10):1-20.
Koufaris C, Sismani C. Modulation of the genome and epigenome of individuals susceptible to autism by environmental risk factors. Int J Mol Sci. 2015; 16(4):8699-8718.
Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Kennedy DN, Filipek PA, et al. Brain asymmetries in autism and
Kalkbrenner AE, Schmidt RJ, Penlesky AC. Environmental chemical exposures and autism spectrum disorders: a review of the epidemiological evidence. Curr Probl Pediatr Adolesc Health Care. 2014; 44(10):277-318.
Pasamanick B, Rogers ME, Lilienfeld AM. Pregnancy experience and the development of behavior disorders in children. Am J Psychiatry. 1956; 112:613-618.
Rutter M, Moffitt TE, Caspi A. Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry. 2006; 47(3-4):226-261.
Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology. 2006; 13(3):171-181.
Christensen J, Gronborg TK, Sorensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013; 309:1696–1703.
Bromley RL, Mawer G, Clayton-Smith J, Baker GA; Liverpool and Manchester Neurodevelopment Group. Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology. 2008; 71:1923–1924.
Ornoy A, Weinstein-Fudim L, Ergaz Z. Prenatal factors associated with autism spectrum disorder (ASD). Reprod Toxicol. 2015; 56:155-169.
Gidaya NB, Lee BK, Burstyn I, Yudell M, Mortensen EL, Newschaffer CJ. In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. J Autism Dev Disord. 2014; 44:2558–2567.
Harrington RA, Lee LC, Crum RM, Zimmerman AW, Hertz-Picciotto I. Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay. Pediatrics. 2014; 133:e1241–1248.
Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med. 2013; 369:2406–2415.
Sorensen MJ, Gronborg TK, Christensen J, Parner ET, Vestergaard M, Schendel D, et al. Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin Epidemiol. 2013; 5:449–459.
Mamidala MP, Polinedi A, P T V PK, Rajesh N, Vallamkonda OR, Udani V, et al. Prenatal, perinatal and neonatal risk factors of Autism Spectrum Disorder: a comprehensive epidemiological assessment from India. Res Dev Disabil. 2013; 34(9):3004-3013.
Shelton JF, Tancredi DJ, Herz-Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res. 2010; 3(1):30-39.
Durkin Ms, Maenner MJ, Newschaffer CJ, Lee LC, Cunniff CM, Daniels JL et al. Advanced parental age and the risk of autism spectrum disorders. Am J Epidemiol. 2008; 168(11):1268-1276.
Croen LA, Najjar DV, Fireman B, Grether JK. Maternal and paternal age and risk of autism spectrum disorders. Arch Pediatr Adolesc Med. 2007; 161(4):334-340.
Reichenberg A, Gross R, Weiser M, Breshanan M, Silverman J, Harlap S et al. Advancing paternal age and autism. Arch Gen Psychiatry. 2006; 63(9):1026-1032.
Sasanfar R, Haddad SA, Tolouei A, Ghadami M, Yu D, Santangelo SL. Paternal age increases the risk for autism in an Iranian population sample. Mol Autism. 2010; 1(1):2.
Burd L, Severud R, Kerbeshian J, Klug MG. Prenatal and perinatal risk factors for autism. J Perinat Med. 1999; 27(6):441-450.
Guinchat V, Thorsen P, Laurent C, Cans C, Bodeau N, Cohen D. Pre-, peri- and neonatal risk factors for autism. Acta Obstet Gynecol Scand. 2012; 91(3):287-300.
Duan G, Yao M, Ma Y, Zhang W. Perinatal and background risk factors for childhood autism in central China. Psychiatry Res. 2014; 220(1-2):410-417.
Anello A, Reichenberg A, Luo X, Schmeidler J, Hollander E, Smith CJ, et al. Brief report: parental age and the sex ratio in autism. J Autism Dev Disord. 2009; 39(10):1487-1492.
Goriely A, McGrath JJ, Hultman CM, Wilkie AO, Malaspina D. "Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. Am J Psychiatry. 2013; 170(6):599-608.
Crow JF. A new study challenges the current belief of a high human male:female mutation ratio. Trends Genet. 2000; 16(12):525–526.
Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, et al. Rate of de novo mutations and the importance of father’s age to disease risk. Nature. 2012; 488(7412):471–475.
Dodds L, Fell DB, Shea S, Armson BA, Allen AC, Bryson S. The role of prenatal, obstetric and neonatal factors in the development of autism. J Autism Dev Disord. 2011; 41(7):891-902.
Zwaigenbaum L, Szatmari P, Jones MB, Bryson SE, MacLean JE, Mahoney WJ. Pregnancy and birth complications in autism and liability to the broader autism phenotype. J Am Acad Child Adolesc Psychiatry. 2002; 41(5):572–579.
Croen LA, Grether JK, Selvin S. Descriptive epidemiology of autism in a California population: Who is at risk? J Autism Dev Disord. 2002; 32(3):217–224.
Glasson EJ, Bower C, Petterson B, de Klerk N, Chaney G, Hallmayer JF. Perinatal factors and the development of autism: A population study. Arch Gen Psychiatry. 2004; 61(6):618–627.
Burstyn I, Sithole F, Zwaigenbaum L. Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Dis Can. 2010; 30(4):125-134.
Depino AM. Maternal infection and the offspring brain. J Neurosci. 2006; 26(30):7777-7778.
Ashwood P, Corbett BA, Kantor A, Schulman H, Van de Water J, Amaral DG. In search of cellular immunophenotypes in the blood of children with autism. PLoS One. 2011; 6(5):e19299.
Maramara LA, He W, Ming X. Pre- and perinatal risk factors for autism spectrum disorder in a New Jersey cohort. J Child Neurol. 2014; 29(12):1645-1651.
Maimburg RD, Vaeth M. Perinatal risk factors and infantile autism. Acta Psychiatr Scand. 2006; 114(4):257-264.
Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology. 2000; 13(4):417–423.
Zhang X, Lv CC, Tian J, Miao RJ, Xi W, Hertz-Picciotto I, Qi L. Prenatal and perinatal risk factors for autism in China. J Autism Dev Disord. 2010; 40(11):1311-21.
Johnson S, Hollis C, Kochhar P, Hennessy E, Wolke D, Marlow N. Autism spectrum disorders in extremely preterm children. J Pediatr. 2010; 156(4):525-31.e2.
Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol. 2005; 161(10):916-925.
Milošević A, Kalanj M, Jovanović J, Čarakovac M, Aleksić B, Pejović-Milovančević M. Early screening for autistic spectrum disorders in toddlers aged 16 to 30 months. Psihijatrija danas 2015; 47(1):63-71.
Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A. Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies. Mol Psychiatry. 2011; 16(12):1203-1212.
Buchmayer S, Johansson S, Johansson A, Hultman CM, Sparén P, Cnattingius S. Can association between preterm birth and autism be explained by maternal or neonatal morbidity? Pediatrics. 2009; 124(5):e817-25.
Haglund NG, Källén KB. Risk factors for autism and Asperger syndrome. Perinatal factors and migration. Autism. 2011; 15(2):163-183.
Maimburg RD, Vaeth M, Schendel DE, Bech BH, Olsen J, Thorsen P. Neonatal jaundice: a risk factor for infantile autism? Paediatr Perinat Emidemiol. 2008; 22(6):562-568.
Maimburg RD, Bech BH, Vaeth M, Moller-Madsen B, Olsen J. Neonatal jaundice, autism, and other disorders of psychological development. Pediatrics. 2010; 126(5):872-878.
Croen LA, Yoshida CK, Odouli R, Newman TB. Neonatal hyperbilirubinaemia and risk of autism spectrum disorders. Pediatrics. 2005; 115(2):e135-8.
Cohen SM. Jaundice in the full term born. Pediatr Nurs. 2006; 32(3):202-208.
Gardener H, Spiegelman D, Buka SL. Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics. 2011; 128(2):344-355.
Tordjman S, Somogyi E, Coulon N, Kermarrec S, Cohen D, Bronsard G, et al. Gene×Environment interactions in autism spectrum disorders: role of epigenetic mechanisms. Front Psychiatry. 2014; 5:53.