Kliničko patološke karakteristike tumora kostiju karlice

Darko Starčević; Ljubica  Simic; Goran Đuričić; Stanislav Rajković; Jelena Sopta

doi:10.5937/mp72-33519

Darko Starčević Medicinski fakultet Univerzitet u Beogradu
Ljubica Simic Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu
Goran Đuričić Univerzitetska dečija klinika ,,Tiršova", Medicinski fakultet, Univerzitet u Beogradu
Stanislav Rajković Institut za ortopediju ,,Banjica", Beograd
Jelena Sopta

DOI: https://doi.org/10.5937/mp72-33519

Ključne reči: Karlica, Kost, Tumor, metastaze, hondrosarkom

Sažetak

Uvod: Koštani tumori su retke neoplazme čija terapija umnogome zavisi od lokalizacije. Kako kosti karlice predstavljaju posebnu anatomsku celinu, dijagnostikovanje i terapija pelvičnih tumora pored patohistološkog tipa umnogome zavisi od anatomskih specifičnosti te regije.

Cilj rada: Cilj ovog rada je bio da se prikaže učestalost, kao i kliničko-patološke karakteristike primarnih i sekundarnih tumora pelvičnih kostiju.

Materijal i metode: Istraživanje je dizajnirano po tipu deskriptivne studije u periodu od 01.01.2019 do 31.12.2019 godine na Institutu za Patologiju Medicinskog fakulteta Univerziteta u Beogradu i uključuje 33 pacijenta. Demografski, klinički i radiološki podaci su dobijeni iz Registra koštanih tumora. Statistička obrada i analiza su urađene u programu Statistical Package for the Social Science SPSS Windows verzija 22 (IBM Chicago, Ilinois, USA).

Rezultati: Od 33 pacijenta, 55% je imalo sekundarne tumore u karličnim kostima, pre svega metastaze karcinoma (37%). U 21% slučajeva, dijagnostikovan je primarni maligni, a u 12% primarni benigni tumor kosti. U 12% su verifikovane hematopoetske neoplazme.

Zaključak: Tumori kostiju karlice nisu česti, ali veliki značaj ovih neoplazmi, u ortopedskoj onkologiji, predstavlja njihovo dominantno maligno biološko ponašanje. Najčešći primarni maligni tumor kod odraslih je hondrosarkom, a kod dece Ewing sarkom. Karcinomi pluća sa najvećom učestalošću metastaziraju u pelvične kosti. Plazmocitom kod odraslih, a Langerhans ćelijska histiocitoza su hematološke neoplazme koje se viđaju na ovoj lokalizaciji.

Ključne reči: Karlica, Kost, Tumor, metastaze, hondrosarkom

Reference

1. Garcia J, Martinez A, Garcia Filho R, Toledo Petrilli M, Viola D. Epidemiological characteristics of patients with pelvic tumors submitted to surgical treatment. Rev. bras. Ortop.2018;53(1): 1982-4378.
2. Vinay K, Abul A, Nelson F, Richard M; Skeletno mišićni sistem; Robinsovi osnovi patologije. Osmo izdanje. Beograd: Data Status; 2010.
3. Atanacković M, Bacetić D, Basta-Jovanović G, Begić-Janeva A, Boričić I, Bršanac D. Patologija; kosti, zglobovi i tumori mekih tkiva. Beograd: Medicinski fakultet Univerziteta u Beogradu katedra za Patologiju; 2015.
4. Girish B, Sunita G, Sujoy G, Sujata M, Priya K. Central Osteoma of Maxilla Associated with an Impacted Tooth: Report of a Rare Case with Literature Review. Head Neck Pathol. 2019; 13(4): 554–561.
5. WHO Classification of Tumours Editorial Board. WHO Classification of Tumours of Soft Tissue and Bone, 5th ed., vol.3, Lyon, France: IARC Press; 2020.
6. Umberto R, Vito Roberto P, Francesco C, Fancesco Pi, Enrico V, Claudia P. Radiofrequency ablation of osteoid osteoma. Acta Biomed. 2018; 89(1): 175–185.
7. Pajić D. Hirurgija odabrana poglavlja: dečijeg, adolescentnog i ranog adultnog doba. Novi Sad: SYMBOL; 2009.
8. Bernstein M, Kovar H, Paulussen M, Randall RL, Schuck A, Teot LA, Juergens H. Ewing's sarcoma family of tumors: current management. Oncologist. 2006; 11(5): 503-519.
9. Lisa M, Rebecca J Ti, Sharon A. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009; 115(7): 1531–1543
10. Garcia-de Marcos JA, Dean-Ferrer A, AlamillosGranados F. Langerhans cell histiocytosis in the maxillofacial area in adultus. Med Oral Patol oral Cir Bucal 2007; 12: 145-50.
11. Arico M, Girchicofsky M, Genereau T, Klersy C, McKlain K, Grous N. Langerhans’ cell histiocytosis in adults. Report from the Internacional Registry of the Histiocyte Society. Eur J Cancer 2003; 39: 2341-8.
12. Malghem J, Lecouvet, F, Kirchgesner T et al. Osteoid osteoma of the hip: imaging features. Skeletal Radiol 2020; 49: 1709–1718
13. Derek A, Mallon Z, Mak W, Borys D Pelvic Osteoid Osteoma in a Skeletally Mature Female. Am J Orthop. 2011; 40(9): 476-478.
14. Prafulla H, Abhijeet S, Pranav P, Pallav Al, Vishal M. A Rare Case of Pubic Ramus Osteochondroma. J Orthop Case Rep. 2015; 5(3): 51–53.
15. Cortese, M.C., Albano, D., Messina, C. et al. Multicentric, multifocal, and recurrent osteoid osteoma of the hip. BMC Musculoskelet Disord. 2019; 171 (2019): 1471-2474.
16. Fitzpatrick KA, Taljanovic MS, Speer DP, Graham AR, Jacobson JA, Barnes GR, Hunter TB. Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 2004;182(6):1389-98.
17. Kaynak B. Conservative treatment of Fibrous Dysplasia. Pak J Med Sci. 2019;35(3):873-876.
18. Yao K, Tang F, Min L, Zhou Y, Chongqi Tu. Multifocal intraosseous hemangioma. Medicine (Baltimore). 2019; 98(2): 14001.
19. Safia A, Steven R, Carola A, Ivy P, Michael H, Peter R, Nadia I. Pelvis Ewing sarcoma: Local control and survival in the modern era. Pediatr Blood Cancer. 2017;64(9): 10.100-26504.
20. Palmerini E, Maki R.G, Staals E.L, Alberghini M, Antonescu C.R, Ferrari C. Primary angiosarcoma of bone: A retrospective analysis of 60 patients from two institutions. Am J Clin Oncol. 2014; 37(6): 528–534.
21. Linabery AM, Ross JA. Trends in childhood cancer incidence in the U.S. (1992–2004). Cancer. 2008; 112:416-432.
22. Nieves G.L, Vilma P, Ana I. B, Javier F, Ramon C, Alfonsa F. Skeletal muscle and solitary bone metastases from malignant melanoma: multimodality imaging and oncological outcome. Melanoma Res. 2018; 28(6):562–570.
23. Gossios K, Argyropoulou M, Stefanaki S, Fotopoulos A, Chrisovitsinos J. Solitary plasmacytoma of the spine in an adolescent: a case report. Pediatr Radiol. 2002; 32(3): 66–369.
24. Riccardo H, Milen M, Itziar A, Eva Š, Vasanta N, Rima J. Langerhans Cell Histiocytosis (LCH): Guidelines for Diagnosis, Clinical Work-Up, and Treatment for Patients Till the Age of 18 Years. Pediatr Blood Cancer. 2013; 60(2): 175–184.
25. Bloem J, Reidsma I. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81(12):3793-801.
26. Girish G, Finlay K, Fessell D, Pai D, Dong Q, Jamadar D. "Imaging Review of Skeletal Tumors of the Pelvis Malignant Tumors and Tumor Mimics. ScientificWorldJournal. 2012; 2012:240281.
27. Vincenzi B, Frezza A.M, Schiavon G, Santini D, Dileo P, Silletta M. Bone metastases in soft tissue sarcoma: a survey of natural history, prognostic value and treatment options. Clin Sarcoma Res. 2013;3(1):2045-3329.
28. Casey D, Wexler L, Meyers A, Magnan H, Chou A, Wolden S. Radiation for Bone Metastases in Ewing Sarcoma and Rhabdomyosarcoma. Pediatr Blood Cancer. 2015; 62(3): 445–449.
29. Puranik A, Purandare N, Bal M, Shah S, Agrawal A, Rangarajan V. Extraskeletal osteosarcoma: An uncommon variant with rare metastatic sites detected with FDG PET/CT. Indian J Med Paediatr Oncol. 2014;35(1):96-8.
30. Sood S, Baheti A.D, Shinagare A.B, Jagannathan J.P, HornickJ.L, Ramaiya N.H. Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients. Br J Radiol.2014; 87(1036): 20130719.