Clinical pathological characteristics of pelvic bone tumors

  • Darko Starčević Faculty of Medicine, University of Belgrade
  • Ljubica Simic Institute of Pathology, Faculty of Medicine, University of Belgrade
  • Goran Djuricic Univerzitetska dečija klinika ,,Tiršova", Medicinski fakultet, Univerzitet u Beogradu
  • Stanislav Rajakovic Institute of Orthopedics "Banjica", Belgrade
  • Jelena Sopta
Keywords: Pelvis, Bone, Tumor, metastases, chondrosarcoma

Abstract


Introduction: Bone tumors are rare neoplasms whose therapy depends on the location. Pelvic bones represent a special anatomical whole, diagnosis and therapy of pelvic tumors in addition to the pathohistological type largely depends on the anatomical specifics of that region.

Aim: The aim of this study was to show the frequency, as well as clinical and pathological characteristics of primary and secondary tumors of the pelvis.

Material and methods: The research as a descriptive study in the period from January 1,  to December 31, 2019 at the Institute of Pathology of the Medical Faculty of the University of Belgrade and includes 33 patients. Demographic, clinical and radiological data were obtained from the Bone Tumor Registry. Statistical processing and analysis were done in the Statistical Package for Social Science SPSS Windows version 22. (IBM Chicago, Ilinois, USA).

Results: Of the 33 patients, 55% had secondary pelvic tumors, primarily cancer metastases (37%). In 21% of cases, primary malignant bone was diagnosed, and in 12%, primary benign bone tumor. Hematopoietic neoplasms were verified in 12%.

Conclusion: Pelvic bone tumors are not common, but of great importance are these neoplasms, in orthopedic oncology, represents their malignant biological behavior. The most common primary malignant tumor in adults is chondrosarcoma, and in children Ewing sarcoma. Lung cancer with they metastasize to the pelvic bones with the highest frequency. Plasmacytoma in adults, Langerhans cellular histiocytosis are hematological neoplasms seen at this site.

Key words: Pelvis, Bone, Tumor, metastases, chondrosarcoma

References

1. Garcia J, Martinez A, Garcia Filho R, Toledo Petrilli M, Viola D. Epidemiological characteristics of patients with pelvic tumors submitted to surgical treatment. Rev. bras. Ortop.2018;53(1): 1982-4378.
2. Vinay K, Abul A, Nelson F, Richard M; Skeletno mišićni sistem; Robinsovi osnovi patologije. Osmo izdanje. Beograd: Data Status; 2010.
3. Atanacković M, Bacetić D, Basta-Jovanović G, Begić-Janeva A, Boričić I, Bršanac D. Patologija; kosti, zglobovi i tumori mekih tkiva. Beograd: Medicinski fakultet Univerziteta u Beogradu katedra za Patologiju; 2015.
4. Girish B, Sunita G, Sujoy G, Sujata M, Priya K. Central Osteoma of Maxilla Associated with an Impacted Tooth: Report of a Rare Case with Literature Review. Head Neck Pathol. 2019; 13(4): 554–561.
5. WHO Classification of Tumours Editorial Board. WHO Classification of Tumours of Soft Tissue and Bone, 5th ed., vol.3, Lyon, France: IARC Press; 2020.
6. Umberto R, Vito Roberto P, Francesco C, Fancesco Pi, Enrico V, Claudia P. Radiofrequency ablation of osteoid osteoma. Acta Biomed. 2018; 89(1): 175–185.
7. Pajić D. Hirurgija odabrana poglavlja: dečijeg, adolescentnog i ranog adultnog doba. Novi Sad: SYMBOL; 2009.
8. Bernstein M, Kovar H, Paulussen M, Randall RL, Schuck A, Teot LA, Juergens H. Ewing's sarcoma family of tumors: current management. Oncologist. 2006; 11(5): 503-519.
9. Lisa M, Rebecca J Ti, Sharon A. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009; 115(7): 1531–1543
10. Garcia-de Marcos JA, Dean-Ferrer A, AlamillosGranados F. Langerhans cell histiocytosis in the maxillofacial area in adultus. Med Oral Patol oral Cir Bucal 2007; 12: 145-50.
11. Arico M, Girchicofsky M, Genereau T, Klersy C, McKlain K, Grous N. Langerhans’ cell histiocytosis in adults. Report from the Internacional Registry of the Histiocyte Society. Eur J Cancer 2003; 39: 2341-8.
12. Malghem J, Lecouvet, F, Kirchgesner T et al. Osteoid osteoma of the hip: imaging features. Skeletal Radiol 2020; 49: 1709–1718
13. Derek A, Mallon Z, Mak W, Borys D Pelvic Osteoid Osteoma in a Skeletally Mature Female. Am J Orthop. 2011; 40(9): 476-478.
14. Prafulla H, Abhijeet S, Pranav P, Pallav Al, Vishal M. A Rare Case of Pubic Ramus Osteochondroma. J Orthop Case Rep. 2015; 5(3): 51–53.
15. Cortese, M.C., Albano, D., Messina, C. et al. Multicentric, multifocal, and recurrent osteoid osteoma of the hip. BMC Musculoskelet Disord. 2019; 171 (2019): 1471-2474.
16. Fitzpatrick KA, Taljanovic MS, Speer DP, Graham AR, Jacobson JA, Barnes GR, Hunter TB. Imaging findings of fibrous dysplasia with histopathologic and intraoperative correlation. AJR Am J Roentgenol. 2004;182(6):1389-98.
17. Kaynak B. Conservative treatment of Fibrous Dysplasia. Pak J Med Sci. 2019;35(3):873-876.
18. Yao K, Tang F, Min L, Zhou Y, Chongqi Tu. Multifocal intraosseous hemangioma. Medicine (Baltimore). 2019; 98(2): 14001.
19. Safia A, Steven R, Carola A, Ivy P, Michael H, Peter R, Nadia I. Pelvis Ewing sarcoma: Local control and survival in the modern era. Pediatr Blood Cancer. 2017;64(9): 10.100-26504.
20. Palmerini E, Maki R.G, Staals E.L, Alberghini M, Antonescu C.R, Ferrari C. Primary angiosarcoma of bone: A retrospective analysis of 60 patients from two institutions. Am J Clin Oncol. 2014; 37(6): 528–534.
21. Linabery AM, Ross JA. Trends in childhood cancer incidence in the U.S. (1992–2004). Cancer. 2008; 112:416-432.
22. Nieves G.L, Vilma P, Ana I. B, Javier F, Ramon C, Alfonsa F. Skeletal muscle and solitary bone metastases from malignant melanoma: multimodality imaging and oncological outcome. Melanoma Res. 2018; 28(6):562–570.
23. Gossios K, Argyropoulou M, Stefanaki S, Fotopoulos A, Chrisovitsinos J. Solitary plasmacytoma of the spine in an adolescent: a case report. Pediatr Radiol. 2002; 32(3): 66–369.
24. Riccardo H, Milen M, Itziar A, Eva Š, Vasanta N, Rima J. Langerhans Cell Histiocytosis (LCH): Guidelines for Diagnosis, Clinical Work-Up, and Treatment for Patients Till the Age of 18 Years. Pediatr Blood Cancer. 2013; 60(2): 175–184.
25. Bloem J, Reidsma I. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81(12):3793-801.
26. Girish G, Finlay K, Fessell D, Pai D, Dong Q, Jamadar D. "Imaging Review of Skeletal Tumors of the Pelvis Malignant Tumors and Tumor Mimics. ScientificWorldJournal. 2012; 2012:240281.
27. Vincenzi B, Frezza A.M, Schiavon G, Santini D, Dileo P, Silletta M. Bone metastases in soft tissue sarcoma: a survey of natural history, prognostic value and treatment options. Clin Sarcoma Res. 2013;3(1):2045-3329.
28. Casey D, Wexler L, Meyers A, Magnan H, Chou A, Wolden S. Radiation for Bone Metastases in Ewing Sarcoma and Rhabdomyosarcoma. Pediatr Blood Cancer. 2015; 62(3): 445–449.
29. Puranik A, Purandare N, Bal M, Shah S, Agrawal A, Rangarajan V. Extraskeletal osteosarcoma: An uncommon variant with rare metastatic sites detected with FDG PET/CT. Indian J Med Paediatr Oncol. 2014;35(1):96-8.
30. Sood S, Baheti A.D, Shinagare A.B, Jagannathan J.P, HornickJ.L, Ramaiya N.H. Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients. Br J Radiol.2014; 87(1036): 20130719.
Published
2022/01/11
Section
Original Scientific Paper