History of gonadotropin use in controlled ovarian stimulation
Keywords:
gonadotropins, history, discovery, infertility
Abstract
The discovery of gonadotropins enabled understanding the complexity of the processes involved in human reproduction. Soon after their discovery gonadotropins were used in the treatment of women with the problem of amenorrhea, anovulation and infertility. This mini-review paper aims to provide historical facts related to the development and application of gonadotropins in reproductive medicine.
References
1. Roque M, Bianco B, Christofolini DM, Barchi Cordts E, Vilarino F, Carvalho W, et al. Pharmacogenetic algorithm for individualized controlled ovarian stimulation in assisted reproductive technology cycles. Panminerva Med. 2019 Mar; 61(1): 76-81.
2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Gonadotropins. 2018 Mar 26. PMID: 31644163.
3. Leão Rde B, Esteves SC. Gonadotropin therapy in assisted reproduction: an evolutionary perspective from biologics to biotech. Clinics (Sao Paulo). 2014; 69(4): 279-93.
4. Lunenfeld B. Historical perspectives in gonadotrophin therapy. Hum Reprod Update. 2004 Nov-Dec; 10(6): 453-67.
5. Fevold SL, Hisaw FL, Leonard SL. The Gonad-stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. Am J Physiol 1931; 97: 291–301.
6. Harrison S, Wolf T, Abuzeid MI. Administration of recombinant follicle stimulating hormone in a woman with allergic reaction to menotropin: a case report. Gynecol Endocrinol. 2000 Jun; 14(3): 149-52.
7. Galliano D. Use of gonadotropins in infertile patients. Fertil Steril. 2017 Sep; 108(3): 455.
8. Ostergaard E. Antigonadotrophic substances. Copenhagen: Ejnar Munksgaard; 1942.
9. Borth R, Lunenfeld B, de Watteville H. Activite gonadotrope d’un extrait d’urines de femmes en menopause. Experientia 1954; 10: 266–270.
10. Romero R. A profile of Bruno Lunenfeld, MD, FRCOG, FACOG (hon). Am J Obstet Gynecol. 2018; 219(3): 225-234.
11. Albert A, Borth R, Diczfalusy E, Loraine JA, Lunenfeld B, McArthur JW, et al. Collaborative assays of two urinary preparations of human pituitary gonadotropin. J Clin Endocrinol Metab. 1958; 18(10): 1117-23.
12. Benz F, Borth R, Brown PS, Crooke AC, Dekanski JB, Diczfalusy E, et al. Collaborative assay of two gonadotrophin preparations from human postmenopausal urine. J Endocrinol. 1959; 19: 158-63.
13. Borth R, Diczfalusy E, Heinrichs HD. Grundlagen der statistischen Auswertung biologischer Bestimmungen. Arch Gynaecol 1957; 188: 497.
14. Borth R, Lunenfeld B, Watteville de H. Le dosage des gonadotrophins—méthode et intérêt clinique. Bull Soc Belge Gynaecol Obstet 1957; 27: 639.
15. Gemzell CA, Diczfalusy E, Tillinger G. Clinical effect of human pituitary follicle stimulating hormone (FSH). J Clin Endcrinol Metab 1958; 18: 1333.
16. Lazarus L. Suspension of the Australian human pituitary hormone programme. Med J Aust. 1985 Jul 22; 143(2): 57-9.
17. Sobel DO, Gutai JP, Rabin BS, Mondino BJ, Fireman P. Pituitary cellular hypersensitivity in idiopathic hypopituitarism. Clin Endocrinol (Oxf). 1984 Mar; 20(3): 341-8.
18. Rathnam P, Saxena BB. Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit. J Biol Chem. 1975; 250(17): 6735-46.
19. Howles CM. Genetic engineering of human FSH (Gonal-F). Hum Reprod Update. 1996; 2(2): 172-91.
20. Practice Committee of American Society for Reproductive Medicine, Birmingham, Alabama. Gonadotropin preparations: past, present, and future perspectives. Fertil Steril. 2008; 90 (5 Suppl): S13-20.
21. Rebar RW. The development of human gonadotropins and their use in infertility: a personalized history. F S Sci. 2020 Nov; 1(2): 106-112.
22. Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P. Beyond the Umbrella: A Systematic Review of the Interventions for the Prevention of and Reduction in the Incidence and Severity of Ovarian Hyperstimulation Syndrome in Patients Who Undergo In Vitro Fertilization Treatments. Int J Mol Sci. 2023 Sep 16; 24(18): 14185.
23. Doroftei B, Ilie OD, Anton N, Marcu OA, Scripcariu IS, Ilea C. A Narrative Review Discussing the Efficiency of Personalized Dosing Algorithm of Follitropin Delta for Ovarian Stimulation and the Reproductive and Clinical Outcomes. Diagnostics (Basel). 2023; 13(2): 177.
2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Gonadotropins. 2018 Mar 26. PMID: 31644163.
3. Leão Rde B, Esteves SC. Gonadotropin therapy in assisted reproduction: an evolutionary perspective from biologics to biotech. Clinics (Sao Paulo). 2014; 69(4): 279-93.
4. Lunenfeld B. Historical perspectives in gonadotrophin therapy. Hum Reprod Update. 2004 Nov-Dec; 10(6): 453-67.
5. Fevold SL, Hisaw FL, Leonard SL. The Gonad-stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. Am J Physiol 1931; 97: 291–301.
6. Harrison S, Wolf T, Abuzeid MI. Administration of recombinant follicle stimulating hormone in a woman with allergic reaction to menotropin: a case report. Gynecol Endocrinol. 2000 Jun; 14(3): 149-52.
7. Galliano D. Use of gonadotropins in infertile patients. Fertil Steril. 2017 Sep; 108(3): 455.
8. Ostergaard E. Antigonadotrophic substances. Copenhagen: Ejnar Munksgaard; 1942.
9. Borth R, Lunenfeld B, de Watteville H. Activite gonadotrope d’un extrait d’urines de femmes en menopause. Experientia 1954; 10: 266–270.
10. Romero R. A profile of Bruno Lunenfeld, MD, FRCOG, FACOG (hon). Am J Obstet Gynecol. 2018; 219(3): 225-234.
11. Albert A, Borth R, Diczfalusy E, Loraine JA, Lunenfeld B, McArthur JW, et al. Collaborative assays of two urinary preparations of human pituitary gonadotropin. J Clin Endocrinol Metab. 1958; 18(10): 1117-23.
12. Benz F, Borth R, Brown PS, Crooke AC, Dekanski JB, Diczfalusy E, et al. Collaborative assay of two gonadotrophin preparations from human postmenopausal urine. J Endocrinol. 1959; 19: 158-63.
13. Borth R, Diczfalusy E, Heinrichs HD. Grundlagen der statistischen Auswertung biologischer Bestimmungen. Arch Gynaecol 1957; 188: 497.
14. Borth R, Lunenfeld B, Watteville de H. Le dosage des gonadotrophins—méthode et intérêt clinique. Bull Soc Belge Gynaecol Obstet 1957; 27: 639.
15. Gemzell CA, Diczfalusy E, Tillinger G. Clinical effect of human pituitary follicle stimulating hormone (FSH). J Clin Endcrinol Metab 1958; 18: 1333.
16. Lazarus L. Suspension of the Australian human pituitary hormone programme. Med J Aust. 1985 Jul 22; 143(2): 57-9.
17. Sobel DO, Gutai JP, Rabin BS, Mondino BJ, Fireman P. Pituitary cellular hypersensitivity in idiopathic hypopituitarism. Clin Endocrinol (Oxf). 1984 Mar; 20(3): 341-8.
18. Rathnam P, Saxena BB. Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit. J Biol Chem. 1975; 250(17): 6735-46.
19. Howles CM. Genetic engineering of human FSH (Gonal-F). Hum Reprod Update. 1996; 2(2): 172-91.
20. Practice Committee of American Society for Reproductive Medicine, Birmingham, Alabama. Gonadotropin preparations: past, present, and future perspectives. Fertil Steril. 2008; 90 (5 Suppl): S13-20.
21. Rebar RW. The development of human gonadotropins and their use in infertility: a personalized history. F S Sci. 2020 Nov; 1(2): 106-112.
22. Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P. Beyond the Umbrella: A Systematic Review of the Interventions for the Prevention of and Reduction in the Incidence and Severity of Ovarian Hyperstimulation Syndrome in Patients Who Undergo In Vitro Fertilization Treatments. Int J Mol Sci. 2023 Sep 16; 24(18): 14185.
23. Doroftei B, Ilie OD, Anton N, Marcu OA, Scripcariu IS, Ilea C. A Narrative Review Discussing the Efficiency of Personalized Dosing Algorithm of Follitropin Delta for Ovarian Stimulation and the Reproductive and Clinical Outcomes. Diagnostics (Basel). 2023; 13(2): 177.
Published
2025/02/23
Section
Mini pregledni članak