Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery

  • Marija Jovanović University of Belgrade – Faculty of Technology and Metallurgy
  • Miloš Petrović University of Belgrade – Faculty of Technology and Metallurgy
  • Dušica Stojanović University of Belgrade – Faculty of Technology and Metallurgy
  • Svetlana Ibrić University in Belgrade – Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology
  • Petar Uskoković University of Belgrade – Faculty of Technology and Metallurgy
Keywords: semi-solid extrusion 3D printing, gelatin-based bone scaffold, in vitro ibuprofen release and kinetics, microindentation, hardness


In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated.  The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.


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Original scientific paper