3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu

  • Marija Jovanović Univerzitet u Beogradu – Tehnološko-metalurški fakultet
  • Miloš Petrović Univerzitet u Beogradu – Tehnološko-metalurški fakultet
  • Dušica Stojanović Univerzitet u Beogradu – Tehnološko-metalurški fakultet
  • Svetlana Ibrić Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju i kozmetologiju
  • Petar Uskoković Univerzitet u Beogradu – Tehnološko-metalurški fakultet
DOI: https://doi.org/10.5937/arhfarm72-40262
Ključne reči: 3D štampa ekstruzijom iz paste, nosač lekova na bazi želatina, in vitro profil i kinetika otpuštanja ibuprofena, mikroindentacija, tvrdoća

Sažetak


Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.

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Objavljeno
2022/12/29
Broj časopisa
Vol. 72 Br. Notebook 6 (2022): Arhiv za farmaciju
Rubrika
Originalni naučni rad
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